3D bioprinting of functional tissue models for personalized drug screening and in vitro disease modeling
Abstract 3D bioprinting is emerging as a promising technology for fabricating complex tissue
constructs with tailored biological components and mechanical properties. Recent advances …
constructs with tailored biological components and mechanical properties. Recent advances …
Three‐dimensional cell culture models for anticancer drug screening: Worth the effort?
ET Verjans, J Doijen, W Luyten… - Journal of cellular …, 2018 - Wiley Online Library
High attrition of new oncology drug candidates in clinical trials is partially caused by the poor
predictive capacity of artificial monolayer cell culture assays early in drug discovery …
predictive capacity of artificial monolayer cell culture assays early in drug discovery …
A critical perspective on 3D liver models for drug metabolism and toxicology studies
AS Serras, JS Rodrigues, M Cipriano… - Frontiers in cell and …, 2021 - frontiersin.org
The poor predictability of human liver toxicity is still causing high attrition rates of drug
candidates in the pharmaceutical industry at the non-clinical, clinical, and post-marketing …
candidates in the pharmaceutical industry at the non-clinical, clinical, and post-marketing …
In vitro models for non-alcoholic fatty liver disease: Emerging platforms and their applications
MJ Ramos, L Bandiera, F Menolascina, JA Fallowfield - Iscience, 2022 - cell.com
Non-alcoholic fatty liver disease (NAFLD) represents a global healthcare challenge,
affecting 1 in 4 adults, and death rates are predicted to rise inexorably. The progressive form …
affecting 1 in 4 adults, and death rates are predicted to rise inexorably. The progressive form …
Spheroids formation on non‐adhesive surfaces by liquid overlay technique: Considerations and practical approaches
EC Costa, D de Melo‐Diogo, AF Moreira… - Biotechnology …, 2018 - Wiley Online Library
Scalable and reproducible production of 3D cellular spheroids is highly demanded, by
pharmaceutical companies, for drug screening purposes during the pre‐clinical evaluation …
pharmaceutical companies, for drug screening purposes during the pre‐clinical evaluation …
Comprehensive evaluation of organotypic and microphysiological liver models for prediction of drug-induced liver injury
Drug-induced liver injury (DILI) is a major concern for the pharmaceutical industry and
constitutes one of the most important reasons for the termination of promising drug …
constitutes one of the most important reasons for the termination of promising drug …
Mitochondria as the target of hepatotoxicity and drug-induced liver injury: molecular mechanisms and detection methods
M Mihajlovic, M Vinken - International journal of molecular sciences, 2022 - mdpi.com
One of the major mechanisms of drug-induced liver injury includes mitochondrial
perturbation and dysfunction. This is not a surprise, given that mitochondria are essential …
perturbation and dysfunction. This is not a surprise, given that mitochondria are essential …
Hybrid bioprinting of chondrogenically induced human mesenchymal stem cell spheroids
L De Moor, S Fernandez, C Vercruysse… - … in Bioengineering and …, 2020 - frontiersin.org
To date, the treatment of articular cartilage lesions remains challenging. A promising
strategy for the development of new regenerative therapies is hybrid bioprinting, combining …
strategy for the development of new regenerative therapies is hybrid bioprinting, combining …
Liver three-dimensional cellular models for high-throughput chemical testing
Drug-induced hepatotoxicity is a leading cause of drug withdrawal from the market. High-
throughput screening utilizing in vitro liver models is critical for early-stage liver toxicity …
throughput screening utilizing in vitro liver models is critical for early-stage liver toxicity …
[HTML][HTML] Using spheroids as building blocks towards 3D bioprinting of tumor microenvironment
Cancer still ranks as a leading cause of mortality worldwide. Although considerable efforts
have been dedicated to anticancer therapeutics, progress is still slow, partially due to the …
have been dedicated to anticancer therapeutics, progress is still slow, partially due to the …