The mammalian/mechanistic target of rapamycin (mTOR) is a key component of cellular
metabolism that integrates nutrient sensing with cellular processes that fuel cell growth and …

Alzheimer's disease (AD) is the most prevalent form of dementia in the elderly population
and has worldwide impact. The etiology of the disease is complex and results from the …

Aging is a major risk factor for age-related ocular diseases including age-related macular
degeneration in the retina and retinal pigment epithelium (RPE), cataracts in the lens …

Endothelial cell dysfunction contributes to age-related vascular diseases. Analyzing public
databases and mouse tissues, we found decreased MFN2 expression in senescent …

Tumor mitochondria alter their functions to reprogram cell metabolism and then allow tumor
cells to rapidly proliferate in the hypoxic and acidic microenvironment. However, roles of …

This study was the first investigation into the main inducers of two lignifications by examining
the changes of physicochemical properties and gene expression in king oyster mushrooms …

Chronic caloric restriction (CR) without malnutrition is known to affect different cellular
processes such as stem cell function, cell senescence, inflammation, and metabolism …

Caffeic acid is a phenolic compound widely synthesized by plants, which has shown health
benefits for multiple aging-related diseases. The aim of this study was to investigate the life …

Background Age is a leading contributor to the liver fibrosis rate and a gradual deterioration
of optical function, but this association in older populations is still under-explored. The …

Sirtuins (SIRT), first described as nicotinamide adenine dinucleotide (NAD+)-dependent
type III histone deacetylases, are produced by cells to support in the defense against chronic …