[HTML][HTML] Repositioning of HMG-CoA reductase inhibitors as adjuvants in the modulation of efflux pump-mediated bacterial and tumor resistance

Z Schelz, HF Muddather, I Zupkó - Antibiotics, 2023 - mdpi.com
Efflux pump (EP)-mediated multidrug resistance (MDR) seems ubiquitous in bacterial
infections and neoplastic diseases. The diversity and lack of specificity of these efflux …

[HTML][HTML] Statins and bempedoic acid: different actions of cholesterol inhibitors on macrophage activation

R Linnenberger, J Hoppstädter, S Wrublewsky… - International Journal of …, 2021 - mdpi.com
Statins represent the most prescribed class of drugs for the treatment of
hypercholesterolemia. Effects that go beyond lipid-lowering actions have been suggested to …

[HTML][HTML] Microbiological status of venous leg ulcers and its predictors: a single-center cross-sectional study

J Cwajda-Białasik, P Mościcka, A Jawień… - International Journal of …, 2021 - mdpi.com
Venous leg ulcers are frequently colonized by microbes. This can be particularly devastating
if the ulcer is infected with alert pathogens, ie, highly virulent microorganisms with well …

Atorvastatin in combination with conventional antimicrobial treatment of Helicobacter pylori eradication: A randomized controlled clinical trial

SS Sarkeshikian, MR Ghadir, F Alemi… - Journal of …, 2020 - Wiley Online Library
Abstract Background and Aim Helicobacter pylori is one of the main causes of digestive
diseases, which is difficult to treat and requires the administration of several antimicrobial …

Statin Use and Reduced Risk of Pneumonia in Patients with Melioidosis: A Lung-Specific Statin Association

TD Coston, SW Wright, R Phunpang… - Annals of the …, 2024 - atsjournals.org
Rationale: 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (statin) use is
associated with a lower risk of incident pneumonia and, less robustly, with nonpulmonary …

[HTML][HTML] Acute Bacterial Infections and Longitudinal Risk of Readmissions and Mortality in Patients Hospitalized with Heart Failure

TMH Ng, EE Oh, YH Bae-Shaaw, E Minejima… - Journal of Clinical …, 2022 - mdpi.com
Aims: Infections are associated with worse short-term outcomes in patients with heart failure
(HF). However, acute infections may have lasting pathophysiologic effects that adversely …

Statin Use Correlates with Reduced Risk of Pyogenic Liver Abscess: A Population‐Based Case–Control Study

KF Liao, KC Cheng, CL Lin… - Basic & Clinical …, 2017 - Wiley Online Library
Little research is available on the relationship between statin use and pyogenic liver
abscess. The objective of the study was to determine whether prior use of statins is …

[HTML][HTML] Inhaled corticosteroids, vitamin K antagonists and amlodipine were associated with an increased risk of acute periprosthetic joint infection in patients with total …

MM Bruin, RLM Deijkers, MPA Bus… - Journal of Clinical …, 2022 - mdpi.com
The perioperative use of certain medication may influence the risk of developing a
periprosthetic joint infection (PJI). Inhaled corticosteroids (ICSs) and cardiovascular drugs …

[HTML][HTML] Sepsis mortality in critical care and prior statin therapy: a retrospective cohort study in central Argentina

LI Paricahua, AFO Goncalves… - Journal of Clinical …, 2017 - ncbi.nlm.nih.gov
Aim The purpose of this study was to describe the clinical outcome of patients diagnosed
with sepsis in a university-affiliated hospital in central Argentina and to evaluate it in relation …

[PDF][PDF] Do statins protect against Respiratory Tract Infection: A systematic review and meta-analysis

SM Alsanosi, AM Alshanberi - Medical Science, 2023 - discoveryjournals.org
Multiple studies have found no significant effect of the lipid-lowering drugs (statins) in
reducing the risk of infections in general. However, there is a paucity of similar data on the …