Influenza A virus (IAV) coopts numerous host factors to complete its replication cycle. Here,
we identify free fatty acid receptor 2 (FFAR2) as a cofactor for IAV entry into host cells. We …

ABSTRACT P-glycoprotein (P-gp) is a key component of the intestinal epithelium playing a
pivotal role in removal of toxins and efflux of endocannabinoids to prevent excessive …

Hydroxycholesterol (25HC) is a biologically active oxysterol, whose production greatly
increases during inflammation by macrophages and dendritic cells. The inflammatory …

Internalization and intracellular trafficking of G protein-coupled receptors (GPCRs) play
pivotal roles in cell responsiveness. Dysregulation in receptor trafficking can lead to aberrant …

Oxytocin plays critical roles in the brain as a neuromodulator, regulating social and other
affective behavior. However, the regulatory mechanisms controlling oxytocin receptor …

Focal adhesion kinase (FAK) regulates key biological processes downstream of G protein-
coupled receptors (GPCRs) in normal and cancer cells, but the modes of kinase activation …

LAM is a rare low-grade metastasizing lung neoplasm. Inhibitors of mTOR improve clinical
outcome of LAM patients by preventing loss of lung function. Nevertheless, other cell targets …

Membrane G protein-coupled receptors (GPCRs) are key components of most eukaryotic
signaling systems, transducing external signals to intracellular effector proteins. Activation of …

In vertebrates, the pituitary gland is a major regulator of physiological processes through the
production and release of chemical signal messengers called hormones. In turn, central …

Аннотация Мембранные рецепторы, сопряженные с G-белками (GPCR), являются
ключевыми компонентами большинства эукариотических сигнальных систем …