With the growing numbers of nanomaterials (NMs), there is a great demand for rapid and
reliable ways of testing NM safety—preferably using in vitro approaches, to avoid the ethical …

Cardiac toxicity represents one of the leading causes of drug failure along different stages of
drug development. Multiple very successful pharmaceuticals had to be pulled from the …

The xCELLigence technology is a real-time cellular biosensor, which measures the net
adhesion of cells to high-density gold electrode arrays printed on custom-designed E-plates …

The microplate assay with Chinese Hamster Ovary (CHO) cells is currently used as a safety
test to monitor the residual pertussis toxin (PT) amount in acellular pertussis antigens prior to …

Nanomedicines are enjoying a widespread popularity realizing their intriguing potential to
solve drug delivery obstacles. Assessment of major quality attributes of nanocarriers is a …

Purpose Tongue cancer is an extremely aggressive disease and is characterized by a poor
prognosis. It is a complex disease to treat and current therapies have produced mediocre …

Abstract Lysyl oxidase-like 2 (LOXL2) is a member of the lysyl oxidase family, which plays
an important role in extracellular matrix protein biosynthesis and tumor progression. In the …

Osteosarcoma, a highly aggressive bone cancer, poses significant treatment challenges.
This study investigates a novel approach utilizing induced pluripotent stem cells (iPSCs) …

Systemic administration of dexmedetomidine provides cardioprotection against
ischemia/reperfusion (I/R) injury; however, the direct effects of dexmedetomidine on …

Abstract Background Real Time Cell Analysis (RTCA) technology is used to monitor cellular
changes continuously over the entire exposure period. Combining with different testing …