MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …

Two opposing models have been proposed to describe the function of the MYC oncoprotein
in shaping cellular transcriptomes: one posits that MYC amplifies transcription at all active …

Just over 25 years ago, MYC, the human homologue of a retroviral oncogene, was
identified. Since that time, MYC research has been intense and the advances impressive …

The JNKs are master protein kinases that regulate many physiological processes, including
inflammatory responses, morphogenesis, cell proliferation, differentiation, survival and …

In multicellular organisms, the total number of cells is a balance between the cell-generating
effects of mitosis and cell death that is induced through apoptosis. A disruption of this …

The idea that conversion of glucose to ATP is an attractive target for cancer therapy has
been supported in part by the observation that glucose deprivation induces apoptosis in …

PUMA (p53 upregulated modulator of apoptosis) is a Bcl-2 homology 3 (BH3)-only Bcl-2
family member and a critical mediator of p53-dependent and-independent apoptosis …

Abstract c-MYC has a pivotal function in growth control, differentiation and apoptosis, and its
abnormal expression is associated with many tumors. Overexpression of c-MYC sensitizes …

Most aspects of mammalian function display circadian rhythms driven by an endogenous
clock. The circadian clock is operated by genes and comprises a central clock in the brain …

The c-Myc oncoprotein promotes proliferation and apoptosis, such that mutations that
disable apoptotic programmes often cooperate with MYC during tumorigenesis. Here we …