Although classically thought of as a motor circuit, the cerebellum is now understood to
contribute to a wide variety of cognitive functions through its dense interconnections with the …

Detailed knowledge about the neural connections among regions of the brain is key for
advancing our understanding of normal brain function and changes that occur with aging …

Throughout mammalian neocortex, layer 5 pyramidal (L5) cells project via the pons to a vast
number of cerebellar granule cells (GrCs), forming a fundamental pathway. Yet, it is …

Sensorimotor integration is crucial to perception and motor control. How and where this
process takes place in the brain is still largely unknown. Here we analyze the cerebellar …

Cognitive processes involve precisely coordinated neuronal communications between
multiple cerebral cortical structures in a task specific manner. Rich new evidence now …

The cerebral cortex and cerebellum both play important roles in sensorimotor processing,
however, precise connections between these major brain structures remain elusive. Using …

We investigated the role of histone methyltransferase Ezh2 in tangential migration of mouse
precerebellar pontine nuclei, the main relay between neocortex and cerebellum. By …

The extent to which different cognitive processes are “embodied” is widely debated.
Previous studies have implicated sensorimotor regions such as lateral intraparietal (LIP) …

The pontine nuclei (PN) are the largest of the precerebellar nuclei, neuronal assemblies in
the hindbrain providing principal input to the cerebellum. The PN are predominantly …

The cerebellum is an essential structure for the control of movement. It sends abundant
ascending projections to the cerebral cortex via the thalamus, but its contribution to cortical …