Inflammasomes are large protein complexes that play a major role in sensing inflammatory
signals and triggering the innate immune response. Each inflammasome complex has three …

Cytoplasmic nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3)
forms an inflammasome with apoptosis-associated speck-like protein containing a CARD …

Chronic kidney disease (CKD) is characterized by inflammation, injury and fibrosis.
Dysregulated innate immune responses mediated by macrophages play critical roles in …

The NLRP3 inflammasome is a cytosolic multiprotein caspase-activating complex platform
involved in innate immunity required for the maturation and release of interleukin (IL)-1β and …

Pyroptosis is a pattern of programmed cell death that significantly differs from apoptosis and
autophagy in terms of cell morphology and function. The process of pyroptosis is …

Inflammasomes, multiprotein complex induced by harmful factors in the body, play a crucial
role in innate immunity. Activation of inflammasomes lead to the activation of casepase-1 …

Immunoglobulin (Ig) A nephropathy (IgAN) is the commonest form of primary
glomerulonephritis worldwide and is, considered a significant cause of end-stage renal …

Chronic kidney disease (CKD) is a global health concern and public health priority. The
condition often involves inflammation due to the accumulation of toxins and the reduced …

Nucleotide-binding oligomerization domain-like receptors (NLRs), including NLRAs, NLRBs
(also known as NAIPs), NLRCs, and NLRPs, are a major subfamily of pattern recognition …

Cell death is involved in a wide range of physiological and pathological processes.
Recently, the term “cuproptosis” was coined to describe a novel type of cell death. This type …