The neuroscience of cancer

R Mancusi, M Monje - Nature, 2023 - nature.com
The nervous system regulates tissue stem and precursor populations throughout life.
Parallel to roles in development, the nervous system is emerging as a critical regulator of …

Glioblastoma remodelling of human neural circuits decreases survival

S Krishna, A Choudhury, MB Keough, K Seo, L Ni… - Nature, 2023 - nature.com
Gliomas synaptically integrate into neural circuits,. Previous research has demonstrated
bidirectional interactions between neurons and glioma cells, with neuronal activity driving …

Synaptic input to brain tumors: clinical implications

V Venkataramani, DI Tanev, T Kuner, W Wick… - Neuro …, 2021 - academic.oup.com
The recent discovery of synaptic connections between neurons and brain tumor cells
fundamentally challenges our understanding of gliomas and brain metastases and shows …

Regional healthy brain activity, glioma occurrence and symptomatology

T Numan, LC Breedt, BAPC Maciel, SD Kulik, J Derks… - Brain, 2022 - academic.oup.com
It is unclear why exactly gliomas show preferential occurrence in certain brain areas.
Increased spiking activity around gliomas leads to faster tumour growth in animal models …

[HTML][HTML] Evaluation of serum extracellular vesicles as noninvasive diagnostic markers of glioma

H Wang, D Jiang, W Li, X Xiang, J Zhao, B Yu… - Theranostics, 2019 - ncbi.nlm.nih.gov
Rationale: Glioma is the most common malignant primary brain tumor in the central nervous
system (CNS). The lack of reliable noninvasive diagnostic and prognostic methods is one of …

Brain tumor-related epilepsy management: A Society for Neuro-oncology (SNO) consensus review on current management

EK Avila, S Tobochnik, SK Inati, JAF Koekkoek… - Neuro …, 2024 - academic.oup.com
Tumor-related epilepsy (TRE) is a frequent and major consequence of brain tumors.
Management of TRE is required throughout the course of disease and a deep …

Symptom networks in glioma patients: understanding the multidimensionality of symptoms and quality of life

JG Röttgering, T Varkevisser, M Gorter… - Journal of Cancer …, 2024 - Springer
Purpose To comprehend the complex relationship between symptoms and health-related
quality of life (HRQoL) in patients with diffuse glioma, we applied symptom network analysis …

Brain network mapping and glioma pathophysiology

AS Mandal, S Brem, J Suckling - Brain Communications, 2023 - academic.oup.com
Adult diffuse gliomas are among the most difficult brain disorders to treat in part due to a lack
of clarity regarding the anatomical origins and mechanisms of migration of the tumours …

Understanding cognitive functioning in glioma patients: The relevance of IDH‐mutation status and functional connectivity

J Derks, S Kulik, P Wesseling, T Numan… - Brain and …, 2019 - Wiley Online Library
Introduction Cognitive deficits occur frequently in diffuse glioma patients, but are limitedly
understood. An important marker for survival in these patients is isocitrate dehydrogenase …

Understanding global brain network alterations in glioma patients

J Derks, SD Kulik, T Numan, PC de Witt Hamer… - Brain …, 2021 - liebertpub.com
Introduction: Glioma patients show increased global brain network clustering related to
poorer cognition and epilepsy. However, it is unclear whether this increase is spatially …