Unicellular flagellates of the family Trypanosomatidae are obligatory parasites of
invertebrates, vertebrates and plants. Dixenous species are aetiological agents of a number …

Protozoan Kinetoplastida, including the pathogenic trypanosomatids of the genera
Trypanosoma and Leishmania, compartmentalize several important metabolic systems in …

Background Leishmania and other intracellular pathogens have evolved strategies that
support invasion and persistence within host target cells. In some cases the underlying …

Peroxisomes are multifunctional organelles with an important role in the generation and
decomposition of reactive oxygen species (ROS). In this review, the ROS-producing …

Ever since the elucidation of the main structural and functional features of eukaryotic cells
and subsequent discovery of the endosymbiotic origin of mitochondria and plastids, two …

Candida albicans, the most important fungal pathogen of humans, has a unique interaction
with macrophages in which phagocytosis induces a switch from the yeast to hyphal form …

Leishmania amastigotes primarily proliferate within macrophages in the mammalian host.
Genome-based metabolic reconstructions, combined with biochemical, reverse genetic and …

Peroxisomes of organisms belonging to the protist group Kinetoplastea, which include
trypanosomatid parasites of the genera Trypanosoma and Leishmania, are unique in …

Sterols are constituents of the cellular membranes that are essential for their normal
structure and function. In mammalian cells, cholesterol is the main sterol found in the various …

The co-infection cases involving dixenous Leishmania spp.(mostly of the L. donovani
complex) and presumably monoxenous trypanosomatids in immunocompromised …