Polycomb group proteins are transcriptional repressors that are essential for normal gene
regulation during development. Recent studies suggest that Polycomb repressive …

Children born small for gestational age (SGA), defined as a birth weight and/or length
below− 2 SD score (SDS), comprise a heterogeneous group. The causes of SGA are …

Global insights into cellular organization and genome function require comprehensive
understanding of the interactome networks that mediate genotype–phenotype relationships …

Structural resolution of protein interactions enables mechanistic and functional studies as
well as interpretation of disease variants. However, structural data is still missing for most …

Centrosomes catalyse the formation of microtubules needed to assemble the mitotic spindle
apparatus. Centrosomes themselves duplicate once per cell cycle, in a process that is …

Abstract The Polycomb group (PcG) protein Enhancer of Zeste Homolog 2 (EZH2) is one of
the three core subunits of the Polycomb Repressive Complex 2 (PRC2). It harbors histone …

The tripartite-motif (TRIM) family of proteins represents one of the largest classes of putative
single protein RING-finger E3 ubiquitin ligases. The members of this family are …

The fast technological development, particularly single nucleotide polymorphism array, array-
comparative genomic hybridization, and whole exome sequencing, has led to the discovery …

Genomic instability is a hallmark of cancer, and has a central role in the initiation and
development of breast cancer,. The success of poly-ADP ribose polymerase inhibitors in the …

Abstract Polycomb repressive complex 1 (PRC1) plays essential roles in cell fate decisions
and development. However, its role in cancer is less well understood. Here, we show that …