High-throughput and single-cell T cell receptor sequencing technologies
JA Pai, AT Satpathy - Nature methods, 2021 - nature.com
T cells express T cell receptors (TCRs) composed of somatically recombined TCRα and
TCRβ chains, which mediate recognition of major histocompatibility complex (MHC)–antigen …
TCRβ chains, which mediate recognition of major histocompatibility complex (MHC)–antigen …
[HTML][HTML] Molecular mimicry and autoimmunity
Molecular mimicry is one of the leading mechanisms by which infectious or chemical agents
may induce autoimmunity. It occurs when similarities between foreign and self-peptides …
may induce autoimmunity. It occurs when similarities between foreign and self-peptides …
T cell receptor therapeutics: immunological targeting of the intracellular cancer proteome
CA Klebanoff, SS Chandran, BM Baker… - Nature Reviews Drug …, 2023 - nature.com
The T cell receptor (TCR) complex is a naturally occurring antigen sensor that detects,
amplifies and coordinates cellular immune responses to epitopes derived from cell surface …
amplifies and coordinates cellular immune responses to epitopes derived from cell surface …
Natural killer cells: from innate to adaptive features
AM Mujal, RB Delconte, JC Sun - Annual review of immunology, 2021 - annualreviews.org
Natural killer (NK) cells are innate lymphocytes that provide critical host defense against
pathogens and cancer. Originally heralded for their early and rapid effector activity, NK cells …
pathogens and cancer. Originally heralded for their early and rapid effector activity, NK cells …
Identifying specificity groups in the T cell receptor repertoire
T cell receptor (TCR) sequences are very diverse, with many more possible sequence
combinations than T cells in any one individual,,,. Here we define the minimal requirements …
combinations than T cells in any one individual,,,. Here we define the minimal requirements …
The burgeoning family of unconventional T cells
While most studies of T lymphocytes have focused on T cells reactive to complexes of
peptide and major histocompatibility complex (MHC) proteins, many other types of T cells do …
peptide and major histocompatibility complex (MHC) proteins, many other types of T cells do …
Immunosequencing identifies signatures of cytomegalovirus exposure history and HLA-mediated effects on the T cell repertoire
An individual's T cell repertoire dynamically encodes their pathogen exposure history. To
determine whether pathogen exposure signatures can be identified by documenting public T …
determine whether pathogen exposure signatures can be identified by documenting public T …
[HTML][HTML] Tumor and microenvironment evolution during immunotherapy with nivolumab
The mechanisms by which immune checkpoint blockade modulates tumor evolution during
therapy are unclear. We assessed genomic changes in tumors from 68 patients with …
therapy are unclear. We assessed genomic changes in tumors from 68 patients with …
Diversity and clonal selection in the human T-cell repertoire
T-cell receptor (TCR) diversity, a prerequisite for immune system recognition of the universe
of foreign antigens, is generated in the first two decades of life in the thymus and then …
of foreign antigens, is generated in the first two decades of life in the thymus and then …
T cell antigen receptor recognition of antigen-presenting molecules
The Major Histocompatibility Complex (MHC) locus encodes classical MHC class I and MHC
class II molecules and nonclassical MHC-I molecules. The architecture of these molecules is …
class II molecules and nonclassical MHC-I molecules. The architecture of these molecules is …