Background Epithelial ovarian cancer presents at an advanced stage in the majority of
women. These women require surgery and chemotherapy for optimal treatment …

Ovarian cancer is characterized by a high mortality on incidence ratio. Although the majority
of patients achieve complete response after primary treatment, approximately 65–80% of …

Background Epithelial ovarian cancer presents at an advanced stage in the majority of
women. These women require a combination of surgery and chemotherapy for optimal …

Primary debulking surgery (PDS) has remained the only treatment of ovarian cancer with
survival advantage since its development in the 1970s. However, survival advantage is only …

Ovarian cancer remains the leading cause of death from gynecological cancer. Survival is
significantly related to the stage of the disease at diagnosis. Of quite importance is primary …

Simple Summary Cytoreductive surgery represents the cornerstone of the management of
advanced epithelial ovarian cancers (aEOC). Currently, two alternative strategies coexist …

Background: Diagnostic methods for the early identification of ovarian cancer (OC) represent
an unmet clinical need, as no reliable diagnostic tools are available. Here, we tested the …

Highlights•Platinum-resistant diseases are related to worst prognosis in ovarian
cancers.•Neoadjuvant chemotherapy may be related to platinum resistance clinically.•Why …

Chemotherapy resistance in ovarian cancer hampers cure rates, with cancer-associated
fibroblasts (CAFs) playing a pivotal role. Despite their known impact on cancer progression …

Objective Neoadjuvant chemotherapy (NACT) represents a treatment option in patients with
advanced epithelial ovarian cancer (AEOC) who are not good candidates for primary …