Past, present and future role of retinal imaging in neurodegenerative disease

AH Kashani, S Asanad, JW Chan, MB Singer… - Progress in retinal and …, 2021 - Elsevier
Retinal imaging technology is rapidly advancing and can provide ever-increasing amounts
of information about the structure, function and molecular composition of retinal tissue in …

[HTML][HTML] The clinical relevance of visualising the peripheral retina

N Quinn, L Csincsik, E Flynn, CA Curcio, S Kiss… - Progress in retinal and …, 2019 - Elsevier
Recent developments in imaging technologies now allow the documentation, qualitative and
quantitative evaluation of peripheral retinal lesions. As wide field retinal imaging, capturing …

Convolutional neural network to identify symptomatic Alzheimer's disease using multimodal retinal imaging

CE Wisely, D Wang, R Henao, DS Grewal… - British Journal of …, 2022 - bjo.bmj.com
Background/Aims To develop a convolutional neural network (CNN) to detect symptomatic
Alzheimer's disease (AD) using a combination of multimodal retinal images and patient data …

Amyloid beta immunoreactivity in the retinal ganglion cell layer of the Alzheimer's eye

S Lee, K Jiang, B McIlmoyle, E To, Q Xu… - Frontiers in …, 2020 - frontiersin.org
Alzheimer's disease (AD) is the most prevalent form of dementia, accounting for 60–70% of
all dementias. AD is often under-diagnosed and recognized only at a later, more advanced …

Ocular manifestations of Alzheimer's and other neurodegenerative diseases: the prospect of the eye as a tool for the early diagnosis of Alzheimer's disease

P Colligris, MJ Perez de Lara… - Journal of …, 2018 - Wiley Online Library
Dementia, including Alzheimer's disease (AD), is a major disorder, leading to several ocular
manifestations amongst the elderly population. These visual disorders may be due to retinal …

Müller cell degeneration and microglial dysfunction in the Alzheimer's retina

QA Xu, P Boerkoel, V Hirsch-Reinshagen… - Acta Neuropathologica …, 2022 - Springer
Amyloid beta (Aβ) deposits in the retina of the Alzheimer's disease (AD) eye may provide a
useful diagnostic biomarker for AD. This study focused on the relationship of Aβ with …

Retina oculomics in neurodegenerative disease

A Suh, J Ong, SA Kamran, E Waisberg… - Annals of Biomedical …, 2023 - Springer
Ophthalmic biomarkers have long played a critical role in diagnosing and managing ocular
diseases. Oculomics has emerged as a field that utilizes ocular imaging biomarkers to …

Salivary exosomes in health and disease: future prospects in the eye

A Liu, B Hefley, P Escandon, SE Nicholas… - International journal of …, 2023 - mdpi.com
Exosomes are a group of vesicles that package and transport DNA, RNA, proteins, and
lipids to recipient cells. They can be derived from blood, saliva, urine, and/or other biological …

Use of ocular biomarkers as a potential tool for early diagnosis of Alzheimer's disease

AK Singh, S Verma - Indian journal of ophthalmology, 2020 - journals.lww.com
Alzheimer's disease (AD) is the most common neurodegenerative disease worldwide which
unfortunately has no known effective cure to date. Despite many clinical trials indicating the …

Ocular biomarkers and their role in the early diagnosis of neurocognitive disorders

IN Chalkias, T Tegos, F Topouzis… - European Journal of …, 2021 - journals.sagepub.com
Given the fact that different types of dementia can be diagnosed only postmortem or when
the disease has progressed enough to cause irreversible damage to certain brain areas …