Lgr5 was originally discovered as a common Wnt target gene in adult intestinal crypts and
colon cancer. It was subsequently identified as an exquisite marker of multiple Wnt-driven …

The four vertebrate R-spondin proteins are secreted agonists of the canonical Wnt/β-catenin
signaling pathway. These proteins are approximately 35 kDa, and are characterized by two …

The adult stem cell marker Lgr5 and its relative Lgr4 are often co-expressed in Wnt-driven
proliferative compartments. We find that conditional deletion of both genes in the mouse gut …

Mammalian epidermis consists of three self-renewing compartments: the hair follicle, the
sebaceous gland, and the interfollicular epidermis. We generated knock-in alleles of murine …

In vivo variations in the concentrations of biomolecular species are inevitable. These
variations in turn propagate along networks of chemical reactions and modify the …

Molecular markers are used to characterize and track adult stem cells. Colon cancer
research has led to the identification of 2 related receptors, leucine-rich repeat–containing …

After its discovery as oncogen and morphogen, studies on Wnt focused initially on its role in
animal development. With the finding that the colorectal tumour suppressor gene APC is a …

The embryonic surface ectoderm gives rise to the epidermis and ectodermal appendages
including hair follicles, teeth, scales, feathers, and mammary, sweat, and salivary glands …

The ultimate success of global efforts to exploit adult stem cells for regenerative medicine
will depend heavily on the availability of robust, highly selective stem cell surface markers …

G-protein-coupled receptor (GPCR) 48 (Gpr48; Lgr4), a newly discovered member of the
glycoprotein hormone receptor subfamily of GPCRs, is an orphan GPCR of unknown …