Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …

Sedentary behaviors (SB) are characterized by low energy expenditure while in a sitting or
reclining posture. Evidence relevant to understanding the physiology of SB can be derived …

Sedentary behaviour—put simply, too much sitting, as a distinct concept from too little
exercise—is a novel determinant of cardiovascular risk. This definition provides a …

In many parts of the world, concerns about the COVID-19 pandemic and city quarantine
policy have led to a general decline in the physical and mental health of residents due to …

The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and
pathogens from entering the brain. At the same time, the BBB regulates transport of …

By 2050, 20% of the world's population will be over the age of 65 years, with projections that
80% of older adults will be living in low-to middle-income countries. Physical inactivity and …

Glycaemic variability is an integral component of glucose homoeostasis. Although it has not
yet been definitively confirmed as an independent risk factor for diabetes complications …

Alzheimer's disease (AD) is a major subtype of neurodegenerative dementia caused by long-
term interactions and accumulation of multiple adverse factors, accompanied by …

Gut microbiome is a community of microorganisms in the gastrointestinal tract. These
bacteria have a tremendous impact on the human physiology in healthy individuals and …

Detrimental associations of sedentary behaviors with depression have been identified, but
findings are inconsistent. We propose a novel approach to the classification and analysis of …