Mesenchymal stromal cells (MSCs) for basic research and clinical applications are
manufactured and developed as unique cell products by many different manufacturers and …

Extracellular vesicles (EVs), including exosomes and microvesicles, are lipid bilayer
particles naturally released from the cell. While exosomes are formed as intraluminal …

A large number of clinical trials have shown stem cell therapy to be a promising therapeutic
approach for the treatment of cardiovascular diseases. Since the first transplantation into …

Background/objectives Induced pluripotent stem cells (iPS) exhibit enhanced survival and
proliferation in ischemic tissues. However, the therapeutic application of iPS cells is limited …

Despite significant therapeutic advances, the prognosis of patients with heart failure (HF)
remains poor, and current therapeutic approaches are palliative in the sense that they do not …

Rationale: Myocardial infarction is a leading cause of death in developed nations, and there
remains a need for cardiac therapeutic systems that mitigate tissue damage. Cardiac …

Exosomes are nanosized membrane particles that are secreted by cells that transmit
information from cell to cell. The information within exosomes prominently includes their …

Rationale: Multiple biological mechanisms contribute to the efficacy of cardiac cell therapy.
Most prominent among these are direct heart muscle and blood vessel regeneration from …

BACKGROUND: Cardiac progenitors (CPC) mediate cardioprotection via paracrine effects.
To date, most of studies focused on secreted paracrine proteins. Here we investigated the …

Myocardial microRNAs (myo-miRs) are released into the circulation after acute myocardial
infarction (AMI). How they impact remote organs is however largely unknown. Here we show …