The success of checkpoint inhibitors has accelerated the clinical implementation of a vast
mosaic of single agents and combination immunotherapies. However, the lack of clinical …

Metabolic abnormalities such as dyslipidemia, hyperinsulinemia, or insulin resistance and
obesity play key roles in the induction and progression of type 2 diabetes mellitus (T2DM) …

Abstract The FOXP3+ CD4+ regulatory T (Treg) cells located in non-lymphoid tissues differ
in phenotype and function from their lymphoid organ counterparts. Tissue Treg cells have …

Diabetic wounds are characterized by drug‐resistant bacterial infections, biofilm formation,
impaired angiogenesis and perfusion, and oxidative damage to the microenvironment …

Regenerative medicine has become one of the hottest research topics in medical science
that provides a promising way for repairing tissue defects in the human body. Due to their …

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Monocytes and lymphocytes play a key role in physiologic wound healing and might be
involved in the impaired mechanisms observed in diabetes. Skin wound macrophages are …

Mesenchymal stem cells (MSCs) are self-renewable, rapidly proliferating, multipotent stem
cells which reside in almost all post-natal tissues. MSCs possess potent immunoregulatory …

The neonatal mouse heart is capable of transiently regenerating after injury from postnatal
day (P) 0-7 and macrophages are found important in this process. However, whether …

Immune cells have emerged as powerful regulators of regenerative as well as pathological
processes. The vast majority of regenerative immunoengineering efforts have focused on …