Infections with the pathogenic free-living amoebae Naegleria fowleri can lead to life-
threatening illnesses including catastrophic primary amoebic meningoencephalitis (PAM) …

Each year, approximately 50,000 children under 5 die as a result of diarrhea caused by
Cryptosporidium parvum, a protozoan parasite. There are currently no effective drugs or …

Abstract ADP-ribosylation factor 1 (ARF1) is a small GTPase that regulates membrane traffic
at the Golgi apparatus and endosomes through recruitment of several coat proteins and lipid …

Genomic sequence interpretation can miss clinically relevant missense variants for several
reasons. Rare missense variants are numerous in the exome and difficult to prioritise …

Nontuberculous mycobacteria (NTM) are emerging human pathogens linked to severe
pulmonary diseases. Current treatments involve the prolonged use of multiple drugs and are …

Onchocerca volvulus causes blindness, onchocerciasis, skin infections and devastating
neurological diseases such as nodding syndrome. New treatments are needed because the …

Thiamin and its phosphate derivatives are ubiquitous molecules involved as essential
cofactors in many cellular processes. The de novo biosynthesis of thiamin employs the …

Because purine nucleotides are essential for all life, differences between how microbes and
humans metabolize purines can be exploited for the development of antimicrobial therapies …

When Toxoplasma gondii egresses from the host cell, glyceraldehyde‐3‐phosphate
dehydrogenase 1 (GAPDH1), which is primary a glycolysis enzyme but actually a …

Haemonchus contortus (H. contortus) ADP-ribosylation factor 1 (Hc-ARF1) and
Hepatocellular carcinoma-associated antigen 59 (Hc-HCA59) are recognized to largely …