Next-generation sequencing for confronting virus pandemics
Virus pandemics have happened, are happening and will happen again. In recent decades,
the rate of zoonotic viral spillover into humans has accelerated, mirroring the expansion of …
the rate of zoonotic viral spillover into humans has accelerated, mirroring the expansion of …
In vitro and in vivo characterization of SARS-CoV-2 strains resistant to nirmatrelvir
M Kiso, Y Furusawa, R Uraki, M Imai… - Nature …, 2023 - nature.com
Nirmatrelvir, an oral antiviral agent that targets a SARS-CoV-2 main protease (3CLpro), is
clinically useful against infection with SARS-CoV-2 including its omicron variants. Since …
clinically useful against infection with SARS-CoV-2 including its omicron variants. Since …
The role of RASs/RVs in the current management of HCV
K Malandris, G Kalopitas, E Theocharidou… - Viruses, 2021 - mdpi.com
The approval of combination therapies with direct-acting antiviral (DAA) regimens has led to
significant progress in the field of hepatitis C virus (HCV) treatment. Although most patients …
significant progress in the field of hepatitis C virus (HCV) treatment. Although most patients …
[HTML][HTML] Real-world effectiveness of voxilaprevir/velpatasvir/sofosbuvir in patients following DAA failure
C Graf, R D'Ambrosio, E Degasperi, S Paolucci… - JHEP Reports, 2024 - Elsevier
Background & Aims Voxilaprevir/velpatasvir/sofosbuvir (VOX/VEL/SOF) is highly effective for
re-treatment of direct-acting antiviral (DAA)-experienced patients with chronic HCV infection …
re-treatment of direct-acting antiviral (DAA)-experienced patients with chronic HCV infection …
MIP-based electrochemical sensor for direct detection of hepatitis C virus via E2 envelope protein
Hepatitis C is the most common liver disease caused by Hepatitis C virus (HCV), and can
evolve into serious health problems eg cirrhosis and hepatocellular carcinoma. Nowadays …
evolve into serious health problems eg cirrhosis and hepatocellular carcinoma. Nowadays …
SARS-CoV-2 mutant spectra at different depth levels reveal an overwhelming abundance of low frequency mutations
B Martínez-González, ME Soria, L Vázquez-Sirvent… - Pathogens, 2022 - mdpi.com
Populations of RNA viruses are composed of complex and dynamic mixtures of variant
genomes that are termed mutant spectra or mutant clouds. This applies also to SARS-CoV …
genomes that are termed mutant spectra or mutant clouds. This applies also to SARS-CoV …
Bioinformatic tools for NGS-based metagenomics to improve the clinical diagnosis of emerging, re-emerging and new viruses
M Ibañez-Lligoña, S Colomer-Castell… - Viruses, 2023 - mdpi.com
Epidemics and pandemics have occurred since the beginning of time, resulting in millions of
deaths. Many such disease outbreaks are caused by viruses. Some viruses, particularly …
deaths. Many such disease outbreaks are caused by viruses. Some viruses, particularly …
Atypical mutational spectrum of SARS-CoV-2 replicating in the presence of ribavirin
P Somovilla, C García-Crespo… - Antimicrobial Agents …, 2023 - Am Soc Microbiol
We report that ribavirin exerts an inhibitory and mutagenic activity on SARS-CoV-2-infecting
Vero cells, with a therapeutic index higher than 10. Deep sequencing analysis of the mutant …
Vero cells, with a therapeutic index higher than 10. Deep sequencing analysis of the mutant …
SARS-CoV-2 point mutation and deletion spectra and their association with different disease outcomes
B Martínez-González, ME Soria… - Microbiology …, 2022 - Am Soc Microbiol
Mutant spectra of RNA viruses are important to understand viral pathogenesis and response
to selective pressures. There is a need to characterize the complexity of mutant spectra in …
to selective pressures. There is a need to characterize the complexity of mutant spectra in …
Emergence and persistence of resistance-associated substitutions in HCV GT3 patients failing direct-acting antivirals
Background: The hepatitis C virus has a high mutation rate, which results in the emergence
of resistance-associated substitutions (RASs). Despite direct-acting antivirals (DAAs) efforts …
of resistance-associated substitutions (RASs). Despite direct-acting antivirals (DAAs) efforts …