Parkinson disease and the immune system—associations, mechanisms and therapeutics

EK Tan, YX Chao, A West, LL Chan, W Poewe… - Nature Reviews …, 2020 - nature.com
Multiple lines of evidence indicate that immune system dysfunction has a role in Parkinson
disease (PD); this evidence includes clinical and genetic associations between autoimmune …

Microbiota-gut-brain axis: new therapeutic opportunities

C Long-Smith, KJ O'Riordan, G Clarke… - Annual review of …, 2020 - annualreviews.org
The traditional fields of pharmacology and toxicology are beginning to consider the
substantial impact our gut microbiota has on host physiology. The microbiota-gut-brain axis …

The Spectrum of Helicobacter-Mediated Diseases

K Robinson, JC Atherton - Annual Review of Pathology …, 2021 - annualreviews.org
Helicobacter pylori is the leading cause of peptic ulcer disease. The infection has been
implicated in more than 75% of duodenal ulcer cases and 17% of gastric ulcer cases. H …

Mechanisms of peripheral levodopa resistance in Parkinson's disease

M Beckers, BR Bloem, MM Verbeek - npj Parkinson's Disease, 2022 - nature.com
Parkinson's disease (PD) is an increasingly common neurodegenerative condition. The
disease has a significant negative impact on quality of life, but a personalized management …

[HTML][HTML] Helicobacter pylori infection: Beyond gastric manifestations

MLC Santos, BB de Brito, FAF da Silva… - World journal of …, 2020 - ncbi.nlm.nih.gov
Helicobacter pylori (H. pylori) is a bacterium that infects more than a half of world's
population. Although it is mainly related to the development of gastroduodenal diseases …

Gastrointestinal barriers to levodopa transport and absorption in Parkinson's disease

V Leta, L Klingelhoefer, K Longardner… - European Journal of …, 2023 - Wiley Online Library
Levodopa is the gold standard for the symptomatic treatment of Parkinson's disease (PD).
There are well documented motor and non‐motor fluctuations, however, that occur almost …

Immune system responses in Parkinson's disease: early and dynamic

MG Tansey, M Romero‐Ramos - European Journal of …, 2019 - Wiley Online Library
The neuropathological hallmarks of Parkinson's disease (PD) are the degeneration and
death of dopamine‐producing neurons in the ventral midbrain, the widespread …

Hospital-treated infections in early-and mid-life and risk of Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis: a nationwide nested case …

J Sun, JF Ludvigsson, C Ingre, F Piehl… - PLoS …, 2022 - journals.plos.org
Background Experimental observations have suggested a role of infection in the etiology of
neurodegenerative disease. In human studies, however, it is difficult to disentangle whether …

Helicobacter pylori infection: a dynamic process from diagnosis to treatment

Q Sun, C Yuan, S Zhou, J Lu, M Zeng, X Cai… - Frontiers in cellular and …, 2023 - frontiersin.org
Helicobacter pylori, a gram-negative microaerophilic pathogen, causes several upper
gastrointestinal diseases, such as chronic gastritis, peptic ulcer disease, and gastric cancer …

Extra-Gastric Manifestations of Helicobacter pylori Infection

AG Gravina, K Priadko, P Ciamarra, L Granata… - Journal of clinical …, 2020 - mdpi.com
Helicobacter Pylori (H. pylori) is a Gram-negative flagellated microorganism that has been
extensively studied since its first isolation due to its widespread diffusion and association …