It is striking that all marketed SARS-CoV-2 vaccines are developed for intramuscular
administration designed to produce humoral and cell mediated immune responses …

Nasal delivery offers many benefits over traditional approaches to vaccine administration.
These include ease of administration without needles that reduces issues associated with …

N, N, N-Trimethylated chitosan (TMC) with varying degree of quaternization (DQ) is currently
being investigated in mucosal drug, vaccine and in gene delivery. However, besides N …

Influenza A viruses causes a variety of illnesses in humans. The most common infection,
seasonal influenza, is usually a mild, self-limited febrile syndrome, but it can be more severe …

For H5N1 influenza immunization, we developed a thermal-sensitive hydrogel as intranasal
vaccine delivery system, which was formulated with N-[(2-hydroxy-3-trimethylammonium) …

Stabilization and ease of administration are two ways to substantially improve the use of
current vaccines. In the present study an influenza whole inactivated virus (WIV) vaccine …

The intranasal administration of proteins using nanoparticles is a promising approach for
several applications, especially for mucosal vaccines. Delivery of protein within the epithelial …

Background The 2009 influenza pandemic and shortages in vaccine supplies worldwide
underscore the need for new approaches to develop more effective vaccines …

Nasal vaccination is a promising, but challenging vaccination strategy. Poor absorption by
the nasal epithelium and failure to break nasal tolerance are regarded as important reasons …

The induction of potent virus-specific immune responses at mucosal surfaces where virus
transmission occurs is a major challenge for vaccination strategies. In the case of influenza …