Targeted drugs have changed cancer treatment but are often ineffective in the long term
against solid tumours, largely because of the activation of heterogeneous oncogenic …

Pin1 is a highly conserved enzyme that only isomerizes specific phosphorylated Ser/Thr-Pro
bonds in certain proteins, thereby inducing conformational changes. Such conformational …

Induced oncoproteins degradation provides an attractive anti-cancer modality. Activation of
anaphase-promoting complex (APC/CCDH1) prevents cell-cycle entry by targeting crucial …

Proline-directed phosphorylation is a posttranslational modification that is instrumental in
regulating signaling from the plasma membrane to the nucleus, and its dysregulation …

Promyelocytic leukemia protein (PML) was originally identified as a fusion partner of retinoic
acid receptor alpha in acute promyelocytic leukemia patients with the (15; 17) chromosomal …

The tumor suppressor promyelocytic leukemia (PML) protein is fused to the retinoic acid
receptor alpha in patients suffering from acute promyelocytic leukemia (APL). Treatment of …

Phosphorylation of proteins on serine or threonine residues preceding proline is a key
signalling mechanism in diverse physiological and pathological processes. Pin1 (peptidyl …

Cyclic peptides have great potential as therapeutic agents and research tools but are
generally impermeable to the cell membrane. Fusion of cyclic peptides with a cyclic cell …

Pin1 is a phospho-specific prolyl isomerase that regulates numerous key signaling
molecules and whose deregulation contributes to disease notably cancer. However, since …

Tumor hypoxia is associated with disease progression and treatment failure, but the hypoxia
signaling mechanism is not fully understood. Here, we show that KLHL20, a Cullin3 (Cul3) …