The isomerase PIN1 controls numerous cancer-driving pathways and is a unique drug target
Targeted drugs have changed cancer treatment but are often ineffective in the long term
against solid tumours, largely because of the activation of heterogeneous oncogenic …
against solid tumours, largely because of the activation of heterogeneous oncogenic …
Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins
Pin1 is a highly conserved enzyme that only isomerizes specific phosphorylated Ser/Thr-Pro
bonds in certain proteins, thereby inducing conformational changes. Such conformational …
bonds in certain proteins, thereby inducing conformational changes. Such conformational …
Reciprocal antagonism of PIN1-APC/CCDH1 governs mitotic protein stability and cell cycle entry
Induced oncoproteins degradation provides an attractive anti-cancer modality. Activation of
anaphase-promoting complex (APC/CCDH1) prevents cell-cycle entry by targeting crucial …
anaphase-promoting complex (APC/CCDH1) prevents cell-cycle entry by targeting crucial …
PML: Regulation and multifaceted function beyond tumor suppression
Promyelocytic leukemia protein (PML) was originally identified as a fusion partner of retinoic
acid receptor alpha in acute promyelocytic leukemia patients with the (15; 17) chromosomal …
acid receptor alpha in acute promyelocytic leukemia patients with the (15; 17) chromosomal …
Differential roles of PML isoforms
The tumor suppressor promyelocytic leukemia (PML) protein is fused to the retinoic acid
receptor alpha in patients suffering from acute promyelocytic leukemia (APL). Treatment of …
receptor alpha in patients suffering from acute promyelocytic leukemia (APL). Treatment of …
Peptidyl-prolyl cis–trans isomerase Pin1 in ageing, cancer and Alzheimer disease
TH Lee, L Pastorino, KP Lu - Expert reviews in molecular medicine, 2011 - cambridge.org
Phosphorylation of proteins on serine or threonine residues preceding proline is a key
signalling mechanism in diverse physiological and pathological processes. Pin1 (peptidyl …
signalling mechanism in diverse physiological and pathological processes. Pin1 (peptidyl …
Cell-permeable bicyclic peptide inhibitors against intracellular proteins
Cyclic peptides have great potential as therapeutic agents and research tools but are
generally impermeable to the cell membrane. Fusion of cyclic peptides with a cyclic cell …
generally impermeable to the cell membrane. Fusion of cyclic peptides with a cyclic cell …
Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function
TH Lee, CH Chen, F Suizu, P Huang… - Molecular cell, 2011 - cell.com
Pin1 is a phospho-specific prolyl isomerase that regulates numerous key signaling
molecules and whose deregulation contributes to disease notably cancer. However, since …
molecules and whose deregulation contributes to disease notably cancer. However, since …
A Cullin3-KLHL20 Ubiquitin ligase-dependent pathway targets PML to potentiate HIF-1 signaling and prostate cancer progression
Tumor hypoxia is associated with disease progression and treatment failure, but the hypoxia
signaling mechanism is not fully understood. Here, we show that KLHL20, a Cullin3 (Cul3) …
signaling mechanism is not fully understood. Here, we show that KLHL20, a Cullin3 (Cul3) …