[HTML][HTML] Parkinson disease-associated cognitive impairment
Parkinson disease (PD) is the second most common neurodegenerative disorder, affecting>
1% of the population≥ 65 years of age and with a prevalence set to double by 2030. In …
1% of the population≥ 65 years of age and with a prevalence set to double by 2030. In …
Parkinson's disease genetics and pathophysiology
GE Vázquez-Vélez, HY Zoghbi - Annual review of neuroscience, 2021 - annualreviews.org
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by
degeneration of the substantia nigra pars compacta and by accumulation of α-synuclein in …
degeneration of the substantia nigra pars compacta and by accumulation of α-synuclein in …
The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability
Alpha-synuclein (αS) is a conformationally plastic protein that reversibly binds to cellular
membranes. It aggregates and is genetically linked to Parkinson's disease (PD). Here, we …
membranes. It aggregates and is genetically linked to Parkinson's disease (PD). Here, we …
Lipid nanoparticle-mediated drug delivery to the brain
Lipid nanoparticles (LNPs) have revolutionized the field of drug delivery through their
applications in siRNA delivery to the liver (Onpattro) and their use in the Pfizer-BioNTech …
applications in siRNA delivery to the liver (Onpattro) and their use in the Pfizer-BioNTech …
Mechanisms of DNA damage‐mediated neurotoxicity in neurodegenerative disease
G Welch, LH Tsai - EMBO reports, 2022 - embopress.org
Neurons are highly susceptible to DNA damage accumulation due to their large energy
requirements, elevated transcriptional activity, and long lifespan. While newer research has …
requirements, elevated transcriptional activity, and long lifespan. While newer research has …
Redox dysregulation as a driver for DNA damage and its relationship to neurodegenerative diseases
Redox homeostasis refers to the balance between the production of reactive oxygen species
(ROS) as well as reactive nitrogen species (RNS), and their elimination by antioxidants. It is …
(ROS) as well as reactive nitrogen species (RNS), and their elimination by antioxidants. It is …
The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson's disease brain as revealed by multicolor STED microscopy
TE Moors, CA Maat, D Niedieker, D Mona… - Acta …, 2021 - Springer
Various post-translationally modified (PTM) proteoforms of alpha-synuclein (aSyn)—
including C-terminally truncated (CTT) and Serine 129 phosphorylated (Ser129-p) aSyn …
including C-terminally truncated (CTT) and Serine 129 phosphorylated (Ser129-p) aSyn …
Alpha-synuclein physiology and pathology: a perspective on cellular structures and organelles
LD Bernal-Conde, R Ramos-Acevedo… - Frontiers in …, 2020 - frontiersin.org
Alpha-synuclein (α-syn) is localized in cellular organelles of most neurons, but many of its
physiological functions are only partially understood. α-syn accumulation is associated with …
physiological functions are only partially understood. α-syn accumulation is associated with …
Alpha-synuclein PET tracer development—an overview about current efforts
Š Korat, NSR Bidesi, F Bonanno, A Di Nanni… - Pharmaceuticals, 2021 - mdpi.com
Neurodegenerative diseases such as Parkinson's disease (PD) are manifested by inclusion
bodies of alpha-synuclein (α-syn) also called α-synucleinopathies. Detection of these …
bodies of alpha-synuclein (α-syn) also called α-synucleinopathies. Detection of these …
P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer's disease
KM Farmer, G Ghag, N Puangmalai… - Acta neuropathologica …, 2020 - Springer
The transcription factor, p53, is critical for many important cellular functions involved in
genome integrity, including cell cycle control, DNA damage response, and apoptosis …
genome integrity, including cell cycle control, DNA damage response, and apoptosis …