[HTML][HTML] Heavy metals, halogenated hydrocarbons, phthalates, glyphosate, cordycepin, alcohol, drugs, and herbs, assessed for liver injury and mechanistic steps

R Teschke, TD Xuan - Frontiers in Bioscience-Landmark, 2022 - imrpress.com
Aluminum, arsenic, cadmium, chromium, cobalt, copper, iron, lead, mercury, nickel, thallium,
titanium, zinc, carbon tetrachloride, phthalates, glyphosate, alcohol, drugs, and herbs are …

[HTML][HTML] Recent update on application of dihydromyricetin in metabolic related diseases

Y Wang, J Wang, H Xiang, P Ding, T Wu, G Ji - Biomedicine & …, 2022 - Elsevier
As a new type of natural flavonoids, dihydromyricetin (DMY) has attracted more and more
attention. It has a series of pharmacological effects, such as anti-inflammatory, anti-tumor …

Classification, hepatotoxic mechanisms, and targets of the risk ingredients in traditional Chinese medicine-induced liver injury

X Pan, J Zhou, Y Chen, X Xie, C Rao, J Liang, Y Zhang… - Toxicology letters, 2020 - Elsevier
Traditional Chinese medicine (TCM) has become a crucial cause of drug-induced liver injury
(DILI). Differ from chemical medicines, TCM feature more complex and mostly indefinite …

A computational systems pharmacology approach to investigate molecular mechanisms of herbal formula Tian-Ma-Gou-Teng-Yin for treatment of Alzheimer's disease

T Wang, Z Wu, L Sun, W Li, G Liu, Y Tang - Frontiers in pharmacology, 2018 - frontiersin.org
Traditional Chinese medicine (TCM) is typically prescribed as formula to treat certain
symptoms. A TCM formula contains hundreds of chemical components, which makes it …

A novel bioinformatics strategy to uncover the active ingredients and molecular mechanisms of Bai Shao in the treatment of non-alcoholic fatty liver disease

S He, H Chen, Y Yi, D Hou, X Fu, J Xie… - Frontiers in …, 2024 - frontiersin.org
Introduction: As a new discipline, network pharmacology has been widely used to disclose
the material basis and mechanism of Traditional Chinese Medicine in recent years …

Network pharmacological mechanisms of Vernonia anthelmintica (L.) in the treatment of vitiligo: Isorhamnetin induction of melanogenesis via up-regulation of …

JY Wang, H Chen, YY Wang, XQ Wang, HY Chen… - BMC Systems …, 2017 - Springer
Background Vitiligo is a long-term skin disease characterized by the loss of pigment in the
skin. The current therapeutic approaches are limited. Although the anti-vitiligo mechanisms …

Research progress on hepatotoxicity mechanism of Polygonum multiflorum and its main components

L Gong, X Shen, N Huang, K Wu, R Li, Y Liu, H Zhang… - Toxicon, 2024 - Elsevier
As a traditional tonic Chinese medicine, Polygonum multiflorum is widely used in clinical
practice. However, with the deepening of modern pharmacological research, its drug toxicity …

admetSAR—A valuable tool for assisting safety evaluation

Y Gu, C Lou, Y Tang - QSAR in safety evaluation and risk assessment, 2023 - Elsevier
Abstract Absorption, distribution, metabolism, excretion, and toxicity (ADMET) play a key role
in safety evaluation and risk assessment. ADMET properties are usually determined by in …

Traditional Chinese Medicine formula, Sanwujiao granule, attenuates ischemic stroke by promoting angiogenesis through early administration

Q Zhou, J Ma, Q Liu, C Wu, Z Yang, T Yang… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Ischemic stroke (IS) is one of the most lethal diseases with
the insufficient pharmacology therapeutic approach. Sanwujiao granule (SW) is widely used …

A Computational Toxicology Approach to Screen the Hepatotoxic Ingredients in Traditional Chinese Medicines: Polygonum multiflorum Thunb as a Case Study

S He, X Zhang, S Lu, T Zhu, G Sun, X Sun - Biomolecules, 2019 - mdpi.com
In recent years, liver injury induced by Traditional Chinese Medicines (TCMs) has gained
increasing attention worldwide. Assessing the hepatotoxicity of compounds in TCMs is …