[HTML][HTML] CRISPR/Cas9 therapeutics: progress and prospects

T Li, Y Yang, H Qi, W Cui, L Zhang, X Fu, X He… - … and Targeted Therapy, 2023 - nature.com
Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated
protein 9 (Cas9) gene-editing technology is the ideal tool of the future for treating diseases …

Precise plant genome editing using base editors and prime editors

KA Molla, S Sretenovic, KC Bansal, Y Qi - Nature Plants, 2021 - nature.com
The development of CRISPR–Cas systems has sparked a genome editing revolution in
plant genetics and breeding. These sequence-specific RNA-guided nucleases can induce …

Heavy metal transporters: Functional mechanisms, regulation, and application in phytoremediation

Z Yang, F Yang, JL Liu, HT Wu, H Yang, Y Shi… - Science of the Total …, 2022 - Elsevier
Heavy metal pollution in soil is a global problem with serious impacts on human health and
ecological security. Phytoextraction in phytoremediation, in which plants uptake and …

[HTML][HTML] Engineering crops of the future: CRISPR approaches to develop climate-resilient and disease-resistant plants

SSA Zaidi, A Mahas, H Vanderschuren, MM Mahfouz - Genome biology, 2020 - Springer
To meet increasing global food demand, breeders and scientists aim to improve the yield
and quality of major food crops. Plant diseases threaten food security and are expected to …

[HTML][HTML] CRISPR for crop improvement: an update review

D Jaganathan, K Ramasamy, G Sellamuthu… - Frontiers in plant …, 2018 - frontiersin.org
The availability of genome sequences for several crops and advances in genome editing
approaches has opened up possibilities to breed for almost any given desirable trait …

CRISPR-Cas9 system: A new-fangled dawn in gene editing

D Gupta, O Bhattacharjee, D Mandal, MK Sen, D Dey… - Life sciences, 2019 - Elsevier
Till date, only three techniques namely Zinc Finger Nuclease (ZFN), Transcription-Activator
Like Effector Nucleases (TALEN) and Clustered Regularly Interspaced Short Palindromic …

[HTML][HTML] DNA-free genetically edited grapevine and apple protoplast using CRISPR/Cas9 ribonucleoproteins

M Malnoy, R Viola, MH Jung, OJ Koo, S Kim… - Frontiers in plant …, 2016 - frontiersin.org
The combined availability of whole genome sequences and genome editing tools is set to
revolutionize the field of fruit biotechnology by enabling the introduction of targeted genetic …

[HTML][HTML] A robust CRISPR/Cas9 system for convenient, high-efficiency multiplex genome editing in monocot and dicot plants

X Ma, Q Zhang, Q Zhu, W Liu, Y Chen, R Qiu, B Wang… - Molecular plant, 2015 - cell.com
CRISPR/Cas9 genome targeting systems have been applied to a variety of species.
However, most CRISPR/Cas9 systems reported for plants can only modify one or a few …

The new frontier of genome engineering with CRISPR-Cas9

JA Doudna, E Charpentier - Science, 2014 - science.org
Background Technologies for making and manipulating DNA have enabled advances in
biology ever since the discovery of the DNA double helix. But introducing site-specific …

[HTML][HTML] Lycopene is enriched in tomato fruit by CRISPR/Cas9-mediated multiplex genome editing

X Li, Y Wang, S Chen, H Tian, D Fu, B Zhu… - Frontiers in plant …, 2018 - frontiersin.org
Numerous studies have been focusing on breeding tomato plants with enhanced lycopene
accumulation, considering its positive effects of fruits on the visual and functional properties …