Down syndrome (DS) is a common cause of intellectual disability and is also associated with
early age of onset of Alzheimer's disease (AD). Due to an extra copy of chromosome 21 …

Importance Recent studies show that cerebral β-amyloid (Aβ) deposition is associated with
blood pressure and measures of arterial stiffness in nondemented individuals. Objective To …

This review focuses on the role of Aβ in AD pathogenesis in Down syndrome and current
approaches for imaging Aβ in vivo. We will describe how Aβ deposits with age, the …

Reduced cerebral blood flow (CBF), an indicator of neurovascular processes and metabolic
demands, is a common finding in Alzheimer's disease. However, little is known about what …

To assess the relationship between carriage of APOE ε4 allele and evolution of white matter
hyperintensities (WMHs) volume, we longitudinally studied 339 subjects from the …

Background and purpose Elevated levels of amyloid deposition as well as white matter
damage are thought to be risk factors for Alzheimer Disease (AD). Here we examined …

Mounting evidence associates a lifetime history of major depression (LMD) with an
increased risk for Alzheimer's disease (AD). Studies have shown that major depression (MD) …

Aims/hypothesis Type 2 diabetes is an independent risk factor for cognitive decline. Insulin
resistance occurring during midlife may increase the risk of cognitive decline later in life. We …

Background Gamma sensory stimulation may reduce AD-specific pathology. Yet, the efficacy
of alternating electrical current stimulation in animal models of AD is unknown, and prior …

Ageing reduces the functional capacity of all organs, so does that of the nervous system; the
latter is evident in the reduction of cognitive abilities, learning and memory. While the exact …