[HTML][HTML] Glucagon-like peptide-1: A multi-faceted anti-inflammatory agent

SF Mehdi, S Pusapati, MS Anwar, D Lohana… - Frontiers in …, 2023 - frontiersin.org
Inflammation contributes to many chronic conditions. It is often associated with circulating
pro-inflammatory cytokines and immune cells. GLP-1 levels correlate with disease severity …

Adaptive immune cells shape obesity-associated type 2 diabetes mellitus and less prominent comorbidities

S SantaCruz-Calvo, L Bharath, G Pugh… - Nature Reviews …, 2022 - nature.com
Obesity and type 2 diabetes mellitus (T2DM) are increasing in prevalence owing to
decreases in physical activity levels and a shift to diets that include addictive and/or high …

Metaflammation in obesity and its therapeutic targeting

MW Schleh, HL Caslin, JN Garcia… - Science translational …, 2023 - science.org
Obesity-associated inflammation is a systemic process that affects all metabolic organs.
Prominent among these is adipose tissue, where cells of the innate and adaptive immune …

[HTML][HTML] Reducing neuroinflammation via therapeutic compounds and lifestyle to prevent or delay progression of Parkinson's disease

E Kip, LC Parr-Brownlie - Ageing Research Reviews, 2022 - Elsevier
Parkinson's disease (PD) is the second most common age-associated neurodegenerative
disorder and is characterised by progressive loss of dopamine neurons in the substantia …

Diabetes, drug treatment, and mortality in COVID-19: a multinational retrospective cohort study

JE Nyland, NT Raja-Khan, K Bettermann, PA Haouzi… - Diabetes, 2021 - Am Diabetes Assoc
Patients with type 2 diabetes mellitus (T2DM) are at increased risk of severe coronavirus
disease 2019 (COVID-19) outcomes possibly because of dysregulated inflammatory …

Low-grade inflammation in type 2 diabetes: a cross-sectional study from a Danish diabetes outpatient clinic

T Okdahl, AM Wegeberg, F Pociot, B Brock, J Størling… - BMJ open, 2022 - bmjopen.bmj.com
Objectives To investigate low-grade inflammation in type 2 diabetes and explore
associations to clinical aspects as well as microvascular and macrovascular complications …

Liraglutide pretreatment attenuates sepsis-induced acute lung injury

B Baer, ND Putz, K Riedmann… - … of Physiology-Lung …, 2023 - journals.physiology.org
There are no effective targeted therapies to treat acute respiratory distress syndrome
(ARDS). Recently, the commonly used diabetes and obesity medications, glucagon-like …

Effect of liraglutide on expression of inflammatory genes in type 2 diabetes

EH Zobel, RS Ripa, BJ von Scholten… - Scientific reports, 2021 - nature.com
Anti-inflammatory effects of glucagon-like peptide 1 receptor agonist (GLP-1 RA) treatment
in T2D may contribute to the cardiovascular benefits observed with GLP-1 RAs in outcome …

The potential of GLP-1 receptor agonists in type 2 diabetes and chronic kidney disease: from randomised trials to clinical practice

BJ von Scholten, FF Kreiner… - Therapeutic …, 2022 - journals.sagepub.com
Chronic kidney disease (CKD) affects around 10% of the global population and is most often
caused by diabetes. Diabetes with CKD (diabetic kidney disease, DKD) is a progressive …

Senescence-associated secretory phenotype of cardiovascular system cells and inflammaging: perspectives of peptide regulation

V Khavinson, N Linkova, A Dyatlova, R Kantemirova… - Cells, 2022 - mdpi.com
A senescence-associated secretory phenotype (SASP) and a mild inflammatory response
characteristic of senescent cells (inflammaging) form the conditions for the development of …