Alpha-synuclein in Parkinson's disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction

P Calabresi, A Mechelli, G Natale… - Cell death & …, 2023 - nature.com
Although the discovery of the critical role of α-synuclein (α-syn) in the pathogenesis of
Parkinson's disease (PD) is now twenty-five years old, it still represents a milestone in PD …

Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments

P Maiti, J Manna, GL Dunbar - Translational neurodegeneration, 2017 - Springer
Gradual degeneration and loss of dopaminergic neurons in the substantia nigra, pars
compacta and subsequent reduction of dopamine levels in striatum are associated with …

Synaptic, mitochondrial, and lysosomal dysfunction in Parkinson's disease

M Nguyen, YC Wong, D Ysselstein, A Severino… - Trends in …, 2019 - cell.com
The discovery of genetic forms of Parkinson's disease (PD) has highlighted the importance
of the autophagy/lysosomal and mitochondrial/oxidative stress pathways in disease …

Immune system responses in Parkinson's disease: early and dynamic

MG Tansey, M Romero‐Ramos - European Journal of …, 2019 - Wiley Online Library
The neuropathological hallmarks of Parkinson's disease (PD) are the degeneration and
death of dopamine‐producing neurons in the ventral midbrain, the widespread …

[HTML][HTML] Modeling α-synuclein propagation with preformed fibril injections

HK Chung, HA Ho, D Pérez-Acuña… - Journal of movement …, 2019 - ncbi.nlm.nih.gov
The aggregation of α-synuclein (α-syn) has been implicated in the pathogenesis of many
neurodegenerative disorders, including Parkinson's disease (PD), dementia with Lewy …

p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's disease

J Chen, K Mao, H Yu, Y Wen, H She, H Zhang… - Journal of …, 2021 - Springer
Background Parkinson's disease (PD) is characterized by degeneration of dopaminergic
neurons in the substantia nigra pars compacta (SNpc), accompanied by accumulation of α …

Glial contribution to excitatory and inhibitory synapse loss in neurodegeneration

CM Henstridge, M Tzioras… - Frontiers in cellular …, 2019 - frontiersin.org
Synapse loss is an early feature shared by many neurodegenerative diseases, and it
represents the major correlate of cognitive impairment. Recent studies reveal that microglia …

Molecular imaging of the dopamine transporter

G Palermo, R Ceravolo - Cells, 2019 - mdpi.com
Dopamine transporter (DAT) single-photon emission tomography (SPECT) with (123)
Ioflupane is a widely used diagnostic tool for patients with suspected parkinsonian …

The pathobiological basis of depression in Parkinson disease: challenges and outlooks

KA Jellinger - Journal of neural transmission, 2022 - Springer
Depression, with an estimated prevalence of about 40% is a most common neuropsychiatric
disorder in Parkinson disease (PD), with a negative impact on quality of life, cognitive …

Alpha-synuclein and lipids: the elephant in the room?

A Sarchione, A Marchand, JM Taymans… - Cells, 2021 - mdpi.com
Since the initial identification of alpha-synuclein (α-syn) at the synapse, numerous studies
demonstrated that α-syn is a key player in the etiology of Parkinson's disease (PD) and other …