Physiological closed-loop control (PCLC) systems: Review of a modern frontier in automation

MJ Khodaei, N Candelino, A Mehrvarz, N Jalili - Ieee Access, 2020 - ieeexplore.ieee.org
Over the past decade, there has been an unprecedented international focus on improved
quality and availability of medical care, which has reignited interest in clinical automation …

Use of 3D anatomical models in mock circulatory loops for cardiac medical device testing

M Rocchi, M Ingram, P Claus, J D'hooge… - Artificial …, 2023 - Wiley Online Library
Abstract Introduction Mock circulatory loops (MCLs) are mechanical representations of the
cardiovascular system largely used to test the hemodynamic performance of cardiovascular …

Estimating model uncertainty of neural networks in sparse information form

J Lee, M Humt, J Feng… - … Conference on Machine …, 2020 - proceedings.mlr.press
We present a sparse representation of model uncertainty for Deep Neural Networks (DNNs)
where the parameter posterior is approximated with an inverse formulation of the …

Continuous heart volume monitoring by fully implantable soft strain sensor

SA Dual, B Llerena Zambrano… - Advanced …, 2020 - Wiley Online Library
Cardiothoracic open‐heart surgery has revolutionized the treatment of cardiovascular
disease, the leading cause of death worldwide. After the surgery, hemodynamic and volume …

An in vitro model to study suction events by a ventricular assist device: validation with clinical data

M Rocchi, C Gross, F Moscato, T Schlöglhofer… - Frontiers in …, 2023 - frontiersin.org
Introduction: Ventricular assist devices (LVADs) are a valuable therapy for end-stage heart
failure patients. However, some adverse events still persist, such as suction that can trigger …

Circulatory Support: Artificial Muscles for the Future of Cardiovascular Assist Devices

I Pirozzi, A Kight, AK Han, MR Cutkosky… - Advanced …, 2023 - Wiley Online Library
Artificial muscles enable the design of soft implantable devices which are poised to
transform the way we mechanically support the heart today. Heart failure is a prevalent and …

Physiologic data-driven iterative learning control for left ventricular assist devices

K Magkoutas, P Arm, M Meboldt… - Frontiers in …, 2022 - frontiersin.org
Continuous flow ventricular assist devices (cfVADs) constitute a viable and increasingly
used therapy for end-stage heart failure patients. However, they are still operating at a fixed …

Non-linearity of end-systolic pressure–volume relation in afterload increases is caused by an overlay of shortening deactivation and the Frank–Starling mechanism

MA Habigt, M Krieger, J Gesenhues, M Ketelhut… - Scientific Reports, 2021 - nature.com
The linearity and load insensitivity of the end-systolic pressure–volume-relationship
(ESPVR), a parameter that describes the ventricular contractile state, are controversial. We …

A sensorless modular multiobjective control algorithm for left ventricular assist devices: A clinical pilot study

M Maw, T Schlöglhofer, C Marko, P Aigner… - Frontiers in …, 2022 - frontiersin.org
Background Contemporary Left Ventricular Assist Devices (LVADs) mainly operate at a
constant speed, only insufficiently adapting to changes in patient demand. Automatic …

Ultrasonic sensor concept to fit a ventricular assist device cannula evaluated using geometrically accurate heart phantoms

SA Dual, JM Zimmermann, J Neuenschwander… - Artificial …, 2019 - Wiley Online Library
Future left ventricular assist devices (LVADs) are expected to respond to the physiologic
need of patients; however, they still lack reliable pressure or volume sensors for feedback …