Epidemiology and treatment of multidrug-resistant and extensively drug-resistant Pseudomonas aeruginosa infections

JP Horcajada, M Montero, A Oliver, L Sorlí… - Clinical microbiology …, 2019 - Am Soc Microbiol
In recent years, the worldwide spread of the so-called high-risk clones of multidrug-resistant
or extensively drug-resistant (MDR/XDR) Pseudomonas aeruginosa has become a public …

Emerging technologies for molecular diagnosis of sepsis

M Sinha, J Jupe, H Mack, TP Coleman… - Clinical microbiology …, 2018 - Am Soc Microbiol
Rapid and accurate profiling of infection-causing pathogens remains a significant challenge
in modern health care. Despite advances in molecular diagnostic techniques, blood culture …

Pathogenesis of Staphylococcus aureus Bloodstream Infections

L Thomer, O Schneewind… - Annual Review of …, 2016 - annualreviews.org
Staphylococcus aureus, a Gram-positive bacterium colonizing nares, skin, and the
gastrointestinal tract, frequently invades the skin, soft tissues, and bloodstreams of humans …

Contribution of Coagulases towards Staphylococcus aureus Disease and Protective Immunity

AG Cheng, M McAdow, HK Kim, T Bae… - PLoS …, 2010 - journals.plos.org
The bacterial pathogen Staphylococcus aureus seeds abscesses in host tissues to replicate
at the center of these lesions, protected from host immune cells via a pseudocapsule. Using …

Role of protein A in the evasion of host adaptive immune responses by Staphylococcus aureus

F Falugi, HK Kim, DM Missiakas, O Schneewind - MBio, 2013 - Am Soc Microbiol
Heritable defects in human B cell/antibody development are not associated with increased
susceptibility to Staphylococcus aureus infection. Protein A (SpA), a surface molecule of S …

Potential targets for next generation antimicrobial glycoconjugate vaccines

F Micoli, P Costantino, R Adamo - FEMS microbiology reviews, 2018 - academic.oup.com
Cell surface carbohydrates have been proven optimal targets for vaccine development.
Conjugation of polysaccharides to a carrier protein triggers a T-cell-dependent immune …

A play in four acts: Staphylococcus aureus abscess formation

AG Cheng, AC DeDent, O Schneewind… - Trends in microbiology, 2011 - cell.com
Staphylococcus aureus is an important human pathogen that causes skin and soft tissue
abscesses. Abscess formation is not unique to staphylococcal infection and purulent …

Effectiveness of practices to increase timeliness of providing targeted therapy for inpatients with bloodstream infections: a laboratory medicine best practices …

SS Buehler, B Madison, SR Snyder… - Clinical microbiology …, 2016 - Am Soc Microbiol
Background. Bloodstream infection (BSI) is a major cause of morbidity and mortality
throughout the world. Rapid identification of bloodstream pathogens is a laboratory practice …

Recurrent infections and immune evasion strategies of Staphylococcus aureus

HK Kim, V Thammavongsa, O Schneewind… - Current opinion in …, 2012 - Elsevier
Staphylococcus aureus causes purulent skin and soft tissue infections (SSTIs) that
frequently reoccur. Staphylococal SSTIs can lead to invasive disease and sepsis, which are …

Preventing Staphylococcus aureus Sepsis through the Inhibition of Its Agglutination in Blood

M McAdow, HK Kim, AC DeDent, APA Hendrickx… - PLoS …, 2011 - journals.plos.org
Staphylococcus aureus infection is a frequent cause of sepsis in humans, a disease
associated with high mortality and without specific intervention. When suspended in human …