Multiple sclerosis (MS) exhibits many of the hallmarks of an inflammatory autoimmune
disorder including breakdown of the blood‐brain barrier (BBB), the recruitment of …

T lymphocytes play a central role in regulation of the immune system. Both effector and
regulatory T cells work in equilibrium to provide optimal immune response against foreign …

T-cells have to recognize peptides presented on MHC molecules to be activated and elicit
their effector functions. Several studies demonstrate that some peptides are more …

To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide
association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid …

Cytolytic T-cells play an essential role in the adaptive immune system by seeking out,
binding and killing cells that present foreign antigens on their surface. An improved …

T cell receptor (TCR) engagement of peptide-major histocompatibility complex (pMHC) is
essential to adaptive immunity, but it is unknown whether TCR signaling responses are …

Studies of individual T cell antigen receptors (TCRs) have shed some light on structural
features that underlie self-reactivity. However, the general rules that can be used to predict …

Major histocompatibility complex (MHC) genes, also known as human leukocyte antigen
genes (HLA) in humans, are the prevailing contributors of genetic susceptibility to …

This review summarizes and integrates research on vitamin D and CD4+ T-lymphocyte
biology to develop new mechanistic insights into the molecular etiology of autoimmune …

Immune tolerance is critical to the avoidance of unwarranted immune responses against self
antigens. Multiple, non-redundant checkpoints are in place to prevent such potentially …