The growth of siRNA-based therapeutics: Updated clinical studies
MM Zhang, R Bahal, TP Rasmussen… - Biochemical …, 2021 - Elsevier
More than two decades after the natural gene-silencing mechanism of RNA interference was
elucidated, small interfering RNA (siRNA)-based therapeutics have finally broken into the …
elucidated, small interfering RNA (siRNA)-based therapeutics have finally broken into the …
[HTML][HTML] An overview of some biopesticides and their importance in plant protection for commercial acceptance
Biopesticides are natural, biologically occurring compounds that are used to control various
agricultural pests infesting plants in forests, gardens, farmlands, etc. There are different …
agricultural pests infesting plants in forests, gardens, farmlands, etc. There are different …
RNA drugs and RNA targets for small molecules: principles, progress, and challenges
RNA-based therapies, including RNA molecules as drugs and RNA-targeted small
molecules, offer unique opportunities to expand the range of therapeutic targets. Various …
molecules, offer unique opportunities to expand the range of therapeutic targets. Various …
The current state and future directions of RNAi-based therapeutics
The RNA interference (RNAi) pathway regulates mRNA stability and translation in nearly all
human cells. Small double-stranded RNA molecules can efficiently trigger RNAi silencing of …
human cells. Small double-stranded RNA molecules can efficiently trigger RNAi silencing of …
Structure of the human DICER–pre-miRNA complex in a dicing state
Dicer has a key role in small RNA biogenesis, processing double-stranded RNAs
(dsRNAs),. Human DICER (hDICER, also known as DICER1) is specialized for cleaving …
(dsRNAs),. Human DICER (hDICER, also known as DICER1) is specialized for cleaving …
[HTML][HTML] Antisense oligonucleotides: an emerging area in drug discovery and development
Antisense oligonucleotides (ASOs) bind sequence specifically to the target RNA and
modulate protein expression through several different mechanisms. The ASO field is an …
modulate protein expression through several different mechanisms. The ASO field is an …
An overview of microRNAs
SM Hammond - Advanced drug delivery reviews, 2015 - Elsevier
The discovery of the first microRNA (miRNA) over 20 years ago has ushered in a new era in
molecular biology. There are now over 2000 miRNAs that have been discovered in humans …
molecular biology. There are now over 2000 miRNAs that have been discovered in humans …
[HTML][HTML] The noncoding RNA revolution—trashing old rules to forge new ones
TR Cech, JA Steitz - Cell, 2014 - cell.com
Noncoding RNAs (ncRNAs) accomplish a remarkable variety of biological functions. They
regulate gene expression at the levels of transcription, RNA processing, and translation …
regulate gene expression at the levels of transcription, RNA processing, and translation …
RNA-mediated epigenetic regulation of gene expression
D Holoch, D Moazed - Nature Reviews Genetics, 2015 - nature.com
Diverse classes of RNA, ranging from small to long non-coding RNAs, have emerged as key
regulators of gene expression, genome stability and defence against foreign genetic …
regulators of gene expression, genome stability and defence against foreign genetic …
Biogenesis and mechanisms of microRNA‐mediated gene regulation
V Rani, RS Sengar - Biotechnology and bioengineering, 2022 - Wiley Online Library
Endogenous RNAs that control posttranscriptional gene expression are microRNAs
(miRNAs). These small regulatory molecules play a crucial role in certain biological …
(miRNAs). These small regulatory molecules play a crucial role in certain biological …