As early as the 19th century, OIH was observed in patients receiving morphine for pain. It
was recognized that a potent analgesic such as morphine could actually result in an …

Opioids are the cornerstone therapy for the treatment of moderate to severe pain. Although
common concerns regarding the use of opioids include the potential for detrimental side …

Background The purpose of this study was to assess whether weaning of opioid use in the
preoperative period improved total joint arthroplasty (TJA) outcomes. Methods Forty-one …

Background Remifentanil-induced secondary hyperalgesia has been documented
experimentally in both animals and healthy human volunteers, but never clinically. This …

Opioid-induced hyperalgesia (OIH) is most broadly defined as a state of nociceptive
sensitization caused by exposure to opioids. The state is characterized by a paradoxical …

Objective To discuss the phenomenon of opioid induced hyperalgesia (OIH) and investigate
the data and clinical recommendations available on this topic. Design A literature search on …

Opioid therapy for chronic pain has been popularized over the past few decades, and a
concern has arisen that the analgesic efficacy of opioids is not always maintained over …

There is accumulating evidence that opioid therapy might not only be associated with the
development of tolerance but also with an increased sensitivity to pain, a condition referred …

Background As in other fields of medicine, development of new medications for
management of neuropathic pain has been difficult since preclinical rodent models do not …

Pain models in animals have shown low predictivity for analgesic efficacy in humans, and
clinical studies are often very confounded, blurring the evaluation. Human experimental pain …