Notch in mechanotransduction–from molecular mechanosensitivity to tissue mechanostasis
OMJA Stassen, T Ristori… - Journal of cell …, 2020 - journals.biologists.com
Tissue development and homeostasis are controlled by mechanical cues. Perturbation of
the mechanical equilibrium triggers restoration of mechanostasis through changes in cell …
the mechanical equilibrium triggers restoration of mechanostasis through changes in cell …
Multiscale computational modeling of vascular adaptation: a systems biology approach using agent-based models
The widespread incidence of cardiovascular diseases and associated mortality and
morbidity, along with the advent of powerful computational resources, have fostered an …
morbidity, along with the advent of powerful computational resources, have fostered an …
A predictive multiscale model of in-stent restenosis in femoral arteries: linking haemodynamics and gene expression with an agent-based model of cellular dynamics
In-stent restenosis (ISR) is a maladaptive inflammatory-driven response of femoral arteries
to percutaneous transluminal angioplasty and stent deployment, leading to lumen re …
to percutaneous transluminal angioplasty and stent deployment, leading to lumen re …
A fully coupled computational fluid dynamics–agent-based model of atherosclerotic plaque development: multiscale modeling framework and parameter sensitivity …
Abstract Background Peripheral Artery Disease (PAD) is an atherosclerotic disorder that
leads to impaired lumen patency through intimal hyperplasia and the build-up of plaques …
leads to impaired lumen patency through intimal hyperplasia and the build-up of plaques …
Computational modeling of in-stent restenosis: Pharmacokinetic and pharmacodynamic evaluation
Persistence of the pathology of in-stent restenosis even with the advent of drug-eluting
stents warrants the development of highly resolved in silico models. These computational …
stents warrants the development of highly resolved in silico models. These computational …
Mechanistic evaluation of long-term in-stent restenosis based on models of tissue damage and growth
Abstract Development and application of advanced mechanical models of soft tissues and
their growth represent one of the main directions in modern mechanics of solids. Such …
their growth represent one of the main directions in modern mechanics of solids. Such …
Intrastent restenosis: a comprehensive review
IT Bajeu, AG Niculescu, A Scafa-Udriște… - International Journal of …, 2024 - mdpi.com
The primary objective of this paper is to delineate and elucidate the contemporary
advancements, developments, and prevailing trajectories concerning intrastent restenosis …
advancements, developments, and prevailing trajectories concerning intrastent restenosis …
A multiphysics modeling approach for in-stent restenosis: Theoretical aspects and finite element implementation
Abstract Development of in silico models that capture progression of diseases in soft
biological tissues are intrinsic in the validation of the hypothesized cellular and molecular …
biological tissues are intrinsic in the validation of the hypothesized cellular and molecular …
Multiscale agent-based modeling of restenosis after percutaneous transluminal angioplasty: effects of tissue damage and hemodynamics on cellular activity
Background Restenosis following percutaneous transluminal angioplasty (PTA) in femoral
arteries is a major cause of failure of the revascularization procedure. The arterial wall …
arteries is a major cause of failure of the revascularization procedure. The arterial wall …
[HTML][HTML] Computational modeling for cardiovascular tissue engineering: the importance of including cell behavior in growth and remodeling algorithms
S Loerakker, T Ristori - Current Opinion in Biomedical Engineering, 2020 - Elsevier
Understanding cardiovascular growth and remodeling (G&R) is fundamental for designing
robust cardiovascular tissue engineering strategies, which enable synthetic or biological …
robust cardiovascular tissue engineering strategies, which enable synthetic or biological …