New insights into activation and function of the AMPK

GR Steinberg, DG Hardie - Nature reviews Molecular cell biology, 2023 - nature.com
The classical role of AMP-activated protein kinase (AMPK) is as a cellular energy sensor
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …

[HTML][HTML] AMPK in skeletal muscle function and metabolism

R Kjøbsted, JR Hingst, J Fentz, M Foretz… - The FASEB …, 2018 - ncbi.nlm.nih.gov
Skeletal muscle possesses a remarkable ability to adapt to various physiologic conditions.
AMPK is a sensor of intracellular energy status that maintains energy stores by fine-tuning …

[HTML][HTML] Exercise, GLUT4, and skeletal muscle glucose uptake

EA Richter, M Hargreaves - Physiological reviews, 2013 - journals.physiology.org
Glucose is an important fuel for contracting muscle, and normal glucose metabolism is vital
for health. Glucose enters the muscle cell via facilitated diffusion through the GLUT4 glucose …

The regulation of fat metabolism during aerobic exercise

A Muscella, E Stefàno, P Lunetti, L Capobianco… - Biomolecules, 2020 - mdpi.com
Since the lipid profile is altered by physical activity, the study of lipid metabolism is a
remarkable element in understanding if and how physical activity affects the health of both …

AMPK—sensing energy while talking to other signaling pathways

DG Hardie - Cell metabolism, 2014 - cell.com
The AMP-activated protein kinase (AMPK) is a sensor of cellular energy and nutrient status,
expressed almost universally in eukaryotes as heterotrimeric complexes comprising catalytic …

AMP-activated protein kinase—an energy sensor that regulates all aspects of cell function

DG Hardie - Genes & development, 2011 - genesdev.cshlp.org
AMP-activated protein kinase (AMPK) is a sensor of energy status that maintains cellular
energy homeostasis. It arose very early during eukaryotic evolution, and its ancestral role …

AMPK: positive and negative regulation, and its role in whole-body energy homeostasis

DG Hardie - Current opinion in cell biology, 2015 - Elsevier
The AMP-activated protein kinase (AMPK) is a sensor of energy status that, when activated
by metabolic stress, maintains cellular energy homeostasis by switching on catabolic …

AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation

GJ Gowans, SA Hawley, FA Ross, DG Hardie - Cell metabolism, 2013 - cell.com
While allosteric activation of AMPK is triggered only by AMP, binding of both ADP and AMP
has been reported to promote phosphorylation and inhibit dephosphorylation at Thr172 …

New strategies in sport nutrition to increase exercise performance

GL Close, DL Hamilton, A Philp, LM Burke… - Free radical biology and …, 2016 - Elsevier
Despite over 50 years of research, the field of sports nutrition continues to grow at a rapid
rate. Whilst the traditional research focus was one that centred on strategies to maximise …

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

M Foretz, S Hébrard, J Leclerc… - The Journal of …, 2010 - Am Soc Clin Investig
Metformin is widely used to treat hyperglycemia in individuals with type 2 diabetes. Recently
the LKB1/AMP-activated protein kinase (LKB1/AMPK) pathway was proposed to mediate the …