New insights into activation and function of the AMPK
GR Steinberg, DG Hardie - Nature reviews Molecular cell biology, 2023 - nature.com
The classical role of AMP-activated protein kinase (AMPK) is as a cellular energy sensor
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …
[HTML][HTML] AMPK in skeletal muscle function and metabolism
R Kjøbsted, JR Hingst, J Fentz, M Foretz… - The FASEB …, 2018 - ncbi.nlm.nih.gov
Skeletal muscle possesses a remarkable ability to adapt to various physiologic conditions.
AMPK is a sensor of intracellular energy status that maintains energy stores by fine-tuning …
AMPK is a sensor of intracellular energy status that maintains energy stores by fine-tuning …
[HTML][HTML] Exercise, GLUT4, and skeletal muscle glucose uptake
EA Richter, M Hargreaves - Physiological reviews, 2013 - journals.physiology.org
Glucose is an important fuel for contracting muscle, and normal glucose metabolism is vital
for health. Glucose enters the muscle cell via facilitated diffusion through the GLUT4 glucose …
for health. Glucose enters the muscle cell via facilitated diffusion through the GLUT4 glucose …
The regulation of fat metabolism during aerobic exercise
A Muscella, E Stefàno, P Lunetti, L Capobianco… - Biomolecules, 2020 - mdpi.com
Since the lipid profile is altered by physical activity, the study of lipid metabolism is a
remarkable element in understanding if and how physical activity affects the health of both …
remarkable element in understanding if and how physical activity affects the health of both …
AMPK—sensing energy while talking to other signaling pathways
DG Hardie - Cell metabolism, 2014 - cell.com
The AMP-activated protein kinase (AMPK) is a sensor of cellular energy and nutrient status,
expressed almost universally in eukaryotes as heterotrimeric complexes comprising catalytic …
expressed almost universally in eukaryotes as heterotrimeric complexes comprising catalytic …
AMP-activated protein kinase—an energy sensor that regulates all aspects of cell function
DG Hardie - Genes & development, 2011 - genesdev.cshlp.org
AMP-activated protein kinase (AMPK) is a sensor of energy status that maintains cellular
energy homeostasis. It arose very early during eukaryotic evolution, and its ancestral role …
energy homeostasis. It arose very early during eukaryotic evolution, and its ancestral role …
AMPK: positive and negative regulation, and its role in whole-body energy homeostasis
DG Hardie - Current opinion in cell biology, 2015 - Elsevier
The AMP-activated protein kinase (AMPK) is a sensor of energy status that, when activated
by metabolic stress, maintains cellular energy homeostasis by switching on catabolic …
by metabolic stress, maintains cellular energy homeostasis by switching on catabolic …
AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation
While allosteric activation of AMPK is triggered only by AMP, binding of both ADP and AMP
has been reported to promote phosphorylation and inhibit dephosphorylation at Thr172 …
has been reported to promote phosphorylation and inhibit dephosphorylation at Thr172 …
New strategies in sport nutrition to increase exercise performance
Despite over 50 years of research, the field of sports nutrition continues to grow at a rapid
rate. Whilst the traditional research focus was one that centred on strategies to maximise …
rate. Whilst the traditional research focus was one that centred on strategies to maximise …
Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
M Foretz, S Hébrard, J Leclerc… - The Journal of …, 2010 - Am Soc Clin Investig
Metformin is widely used to treat hyperglycemia in individuals with type 2 diabetes. Recently
the LKB1/AMP-activated protein kinase (LKB1/AMPK) pathway was proposed to mediate the …
the LKB1/AMP-activated protein kinase (LKB1/AMPK) pathway was proposed to mediate the …