Background: The prenatal environment influences lifetime health; epigenetic mechanisms
likely predominate. In 2016, the first international consortium paper on cigarette smoking …

Understanding the biological mechanisms underlying tick resistance in cattle holds the
potential to facilitate genetic improvement through selective breeding. Genome wide …

Objective Mechanisms underlying the adolescent‐onset and early‐onset gout are unclear.
This study aimed to discover variants associated with early‐onset gout. Methods We …

Whole-genome data has become significantly more accessible over the last two decades.
This can largely be attributed to both reduced sequencing costs and imputation models …

Economists and social scientists have debated the relative importance of nature (one's
genes) and nurture (one's environment) for decades, if not centuries. This debate can now …

Cystic fibrosis (CF) is a severe genetic disorder that can cause multiple comorbidities
affecting the lungs, the pancreas, the luminal digestive system and beyond. In our previous …

Genotype imputation is widely used to enrich genetic datasets. The operation relies on
panels of known reference haplotypes, typically with whole-genome sequencing data. How …

The predictive ability of coronary heart disease (CHD) and ischemic stroke (IS) polygenic
risk scores (PRS) have been evaluated individually, but whether they predict the combined …

The current inhabitants of the Canary Islands have a unique genetic makeup in the
European diversity landscape due to the existence of African footprints from recent …

Advances in technologies to measure a broad set of exposures have led to a range of
exposome research efforts. Yet, these efforts have insufficiently integrated methods that …