The immune system of the central nervous system (CNS) consists primarily of innate
immune cells. These are highly specialized macrophages found either in the parenchyma …

As extremely sensitive immune cells, microglia act as versatile watchdogs of the central
nervous system (CNS) that tightly control tissue homeostasis. Therefore, microglial activation …

A hallmark of nervous system aging is a decline of white matter volume and function, but the
underlying mechanisms leading to white matter pathology are unknown. In the present …

Notable advances in gene sequencing methods in recent years have permitted enormous
progress in the phenotypic and genotypic characterization of autoinflammatory syndromes …

Microglia, the resident myeloid cells in the central nervous system (CNS) play critical roles in
shaping the brain during development, responding to invading pathogens, and clearing …

Background Tau is aberrantly acetylated in various neurodegenerative conditions, including
Alzheimer's disease, frontotemporal lobar degeneration (FTLD), and traumatic brain injury …

The interferon (IFN)-stimulated gene product 15 (ISG15) represents an ubiquitin-like protein
(Ubl), which in a process termed ISGylation can be covalently linked to target substrates via …

Microglia are parenchymal macrophages of the CNS; as professional phagocytes they are
important for maintenance of the brain's physiology. These cells are generated through …

Post-translational modifications play major roles in the stability, function, and localization of
target proteins involved in the nervous system. The ubiquitin-proteasome pathway uses …

Abstract Three Prime Repair Exonuclease 1 (TREX1) gene mutations have been associated
with Aicardi-Goutières Syndrome (AGS)–a rare, severe pediatric autoimmune disorder that …