The eukaryotic ubiquitin family encompasses nearly 20 proteins that are involved in the
posttranslational modification of various macromolecules. The ubiquitin-like proteins (UBLs) …

Neurons are highly specialized cells whose connectivity at synapses subserves rapid
information transfer in the brain. Proper information processing, learning, and memory …

Reversible protein modification by small ubiquitin-like modifiers (SUMOs) is critical for
eukaryotic life. Mass spectrometry-based proteomics has proven effective at identifying …

The cellular response to DNA damage employs multiple dynamic protein modifications to
exert rapid and adaptable effects. Substantial work has detailed the roles of canonical …

Protein ubiquitination is an essential post-translational modification regulating
neurodevelopment, synaptic plasticity, learning, and memory, and its dysregulation …

Aberrant expression, activation, and stabilization of epidermal growth factor receptor (EGFR)
are causally associated with several human cancers. Post-translational modifications and …

Here we describe a systematic structure-function analysis of the human ubiquitin (Ub) E2
conjugating proteins, consisting of the determination of 15 new high-resolution three …

In the last decade, proteomic technologies have been increasingly used in fish biology
research. Proteomics has been applied primarily to investigate the physiology, development …

The paramyxovirus matrix (M) protein is a molecular scaffold required for viral
morphogenesis and budding at the plasma membrane. Transient nuclear residence of some …

The telomere-capping complex shelterin protects functional telomeres and prevents the
initiation of unwanted DNA-damage-response pathways. At the end of cellular replicative …