The cloning of a G protein-coupled extracellular Ca2+ (Cao 2+)-sensing receptor (CaR) has
elucidated the molecular basis for many of the previously recognized effects of Cao 2+ on …

Glutamate receptor-mediated excitatory neurotransmission plays a key role in neural
development, differentiation and synaptic plasticity. However, excessive stimulation of …

Retinal hypoxia is the potentially blinding mechanism underlying a number of sight-
threatening disorders including central retinal artery occlusion, ischemic central retinal vein …

Metabotropic glutamate (mGlu) receptors have been considered as potential targets for
neuroprotective drugs, but the lack of specific drugs has limited the development of …

Alzheimer's disease (AD) ranks sixth on the Centers for Disease Control and Prevention Top
10 Leading Causes of Death list for 2016, and the Alzheimer's Association attributes 60% to …

Medium spiny neurons were recorded from striatal slices obtained from mice lacking the
group I metabotropic glutamate receptor (mGluR) subtype 1 or subtype 5. In wild-type …

Metabotropic glutamate (mGlu) receptors are a large, heterogeneous family of G-protein
coupled receptors, which modulate excitatory synaptic transmission through various …

Striatal neurones receive myriad of synaptic inputs originating from different sources.
Massive afferents from all areas of the cortex and the thalamus represent the most important …

The medium collected from cultured astrocytes transiently exposed to the group-II
metabotropic glutamate (mGlu) receptor agonists (2S, 1′ R, 2′ R, 3′ R)-2-(2, 3 …

Glutamate is the major excitatory neurotransmitter in the brain and plays a unique role in a
variety of central nervous system (CNS) functions. The discovery of the metabotropic …