Resident microglial cells can be regarded as the immunological watchdogs of the brain and
the retina. They are active sensors of their neuronal microenvironment and rapidly respond …

For many retinal diseases, including age-related macular degeneration (AMD), glaucoma,
and diabetic retinopathy (DR), the exact pathogenesis is still unclear. Moreover, the currently …

Elimination of senescent cells (senolysis) was recently reported to improve normal and
pathological changes associated with aging in mice,. However, most senolytic agents inhibit …

Summary The apolipoprotein E4 (APOE4) allele is associated with an increased risk of
Alzheimer disease and a decreased risk of glaucoma, but the underlying mechanisms …

Glaucomas are neurodegenerative diseases that cause vision loss, especially in the elderly.
The mechanisms initiating glaucoma and driving neuronal vulnerability during normal aging …

Despite high metabolic activity, the retina and optic nerve head lack traditional lymphatic
drainage. We here identified an ocular glymphatic clearance route for fluid and wastes via …

Glaucoma is one of the most common neurodegenerative diseases. Despite this, the earliest
stages of this complex disease are still unclear. This study was specifically designed to …

Here, we use a mouse model (DBA/2J) to readdress the location of insult (s) to retinal
ganglion cells (RGCs) in glaucoma. We localize an early sign of axon damage to an …

Brain tumors are horrific diseases with almost universally fatal outcomes; new therapeutics
are desperately needed and will come from improved understandings of glioma biology …

Glaucoma is a common optic neuropathy with a complex etiology often linked to sensitivity to
intraocular pressure. Though the precise mechanisms that mediate or transduce this …