Inflammatory responses play pivotal roles in cancer development, including tumor initiation,
promotion, progression, and metastasis. Cytokines are now recognized as important …

Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell disorders
characterized by activated Janus kinase (JAK)–signal transducer and activator of …

The mammalian Target of Rapamycin (mTOR) pathway plays an essential role in sensing
and integrating a variety of exogenous cues to regulate cellular growth and metabolism, in …

Major progress has been recently made in understanding the molecular pathogenesis of
myeloproliferative neoplasms (MPN). Mutations in one of four genes—JAK2, MPL, CALR …

Background Aberrant activation of STAT3 is frequently encountered and promotes survival,
cellular proliferation, migration, invasion and angiogenesis in tumor cell. Convallatoxin …

Optimal regulation of immune networks is essential for the generation of effective immune
responses, and defects in such networks can lead to immunodeficiency while uncontrolled …

Cancer is a major threat to human health, with high mortality and a low cure rate,
continuously challenging public health worldwide. Extensive clinical application of …

There has been a major revolution in the management of patients with myeloproliferative
neoplasms (MPN), and in particular those with myelofibrosis and extensive splenomegaly …

The mTOR pathway plays a central role in many cellular processes, such as cellular growth,
protein synthesis, glucose, and lipid metabolism. Aberrant regulation of mTOR is a hallmark …

A complex interplay of intracellular signaling networks orchestrates normal cell growth and
survival, including translation, transcription, proliferation, and cell cycle progression …