Compaction and control—the role of chromosome-organizing proteins in Streptomyces

MJ Szafran, D Jakimowicz… - FEMS Microbiology …, 2020 - academic.oup.com
Chromosomes are dynamic entities, whose organization and structure depend on the
concerted activity of DNA-binding proteins and DNA-processing enzymes. In bacteria …

[HTML][HTML] Binding Pattern and Structural Interactome of the Anticancer Drug 5-Fluorouracil: A Critical Review

ES Lin, CY Huang - International Journal of Molecular Sciences, 2024 - mdpi.com
5-Fluorouracil (5-FU) stands as one of the most widely prescribed chemotherapeutics.
Despite over 60 years of study, a systematic synopsis of how 5-FU binds to proteins has …

[HTML][HTML] Crystal Structure of an SSB Protein from Salmonella enterica and Its Inhibition by Flavanonol Taxifolin

ES Lin, YH Huang, RH Luo, Z Basharat… - International Journal of …, 2022 - mdpi.com
Single-stranded DNA (ssDNA)-binding proteins (SSBs) play a central role in cells by
participating in DNA metabolism, including replication, repair, recombination, and replication …

[HTML][HTML] Crystal Structure of DNA Replication Protein SsbA Complexed with the Anticancer Drug 5-Fluorouracil

HH Su, YH Huang, Y Lien, PC Yang… - International Journal of …, 2023 - mdpi.com
Single-stranded DNA-binding proteins (SSBs) play a crucial role in DNA metabolism by
binding and stabilizing single-stranded DNA (ssDNA) intermediates. Through their …

[HTML][HTML] Characterization of the Chimeric PriB-SSBc Protein

ES Lin, YH Huang, CY Huang - International Journal of Molecular …, 2021 - mdpi.com
PriB is a primosomal protein required for the replication fork restart in bacteria. Although PriB
shares structural similarity with SSB, they bind ssDNA differently. SSB consists of an N …

Crystal structure of the single-stranded DNA-binding protein SsbB in complex with the anticancer drug 5-fluorouracil: Extension of the 5-fluorouracil interactome to …

ES Lin, CY Huang - Biochemical and Biophysical Research …, 2021 - Elsevier
Single-stranded DNA-binding proteins (SSBs) are essential to cells because they participate
in DNA metabolic processes, such as DNA replication, repair, and recombination. Some …

[HTML][HTML] Characterization of an SSB–dT25 complex: structural insights into the S-shaped ssDNA binding conformation

YH Huang, IC Chen, CY Huang - RSC advances, 2019 - pubs.rsc.org
Single-stranded DNA (ssDNA)-binding proteins (SSBs) play an important role in all DNA-
dependent cellular processes, such as DNA replication, recombination, repair, and …

[HTML][HTML] SAAV2152 is a single-stranded DNA binding protein: The third SSB in Staphylococcus aureus

YH Huang, CY Huang - Oncotarget, 2018 - ncbi.nlm.nih.gov
Single-stranded DNA-binding proteins (SSBs) play crucial roles in DNA replication, repair,
and recombination. Unlike E. coli, which contains only one type of SSB (EcSSB), some …

Impact of C-terminal domains of paralogous single-stranded DNA binding proteins from Streptomyces coelicolor on their biophysical properties and biological …

G Pipalović, Ž Filić, M Ćehić, T Paradžik… - International journal of …, 2024 - Elsevier
Single-stranded DNA-binding proteins (SSB) are crucial in DNA metabolism. While
Escherichia coli SSB is extensively studied, the significance of its C-terminal domain has …

A data-driven structural model of hSSB1 (NABP2/OBFC2B) self-oligomerization

C Touma, MN Adams, NW Ashton, M Mizzi… - Nucleic acids …, 2017 - academic.oup.com
The maintenance of genome stability depends on the ability of the cell to repair DNA
efficiently. Single-stranded DNA binding proteins (SSBs) play an important role in DNA …