Resistance to therapeutic treatment and metastatic progression jointly determine a fatal
outcome of cancer. Cancer metastasis and therapeutic resistance are traditionally studied as …

The way in which cells coordinate their behaviours during various biological processes,
including morphogenesis, cancer progression and tissue remodelling, largely depends on …

Plasticity of cancer invasion and metastasis depends on the ability of cancer cells to switch
between collective and single-cell dissemination, controlled by cadherin-mediated cell–cell …

Chronic diabetic wounds are a significant global healthcare challenge. Current strategies,
such as biomaterials, cell therapies, and medical devices, however, only target a few …

Collective cell migration has a key role during morphogenesis and during wound healing
and tissue renewal in the adult, and it is involved in cancer spreading. In addition to …

Chemical and physical properties of the environment control cell proliferation, differentiation,
or apoptosis in the long term. However, to be able to move and migrate through a complex …

In epithelial cancers, cells must invade through basement membranes (BMs) to metastasize.
The BM, a thin layer of extracellular matrix underlying epithelial and endothelial tissues, is …

The wound healing assay is used in a range of disciplines to study the coordinated
movement of a cell population. In this technical review, we describe the workflow of the …

During collective migration of epithelial cells, the migration direction is aligned over a tissue-
scale expanse. Although the collective cell migration is known to be directed by mechanical …

Collective cell migration critically depends on cell–cell interactions coupled to a dynamic
actin cytoskeleton. Important cell–cell adhesion receptor systems implicated in controlling …