Population genomics of Klebsiella pneumoniae

KL Wyres, MMC Lam, KE Holt - Nature Reviews Microbiology, 2020 - nature.com
Klebsiella pneumoniae is a common cause of antimicrobial-resistant opportunistic infections
in hospitalized patients. The species is naturally resistant to penicillins, and members of the …

[HTML][HTML] Carbapenem-Resistant Klebsiella pneumoniae: Virulence Factors, Molecular Epidemiology and Latest Updates in Treatment Options

T Karampatakis, K Tsergouli, P Behzadi - Antibiotics, 2023 - mdpi.com
Klebsiella pneumoniae is a Gram-negative opportunistic pathogen responsible for a variety
of community and hospital infections. Infections caused by carbapenem-resistant K …

Clinical outcomes and bacterial characteristics of carbapenem-resistant Klebsiella pneumoniae complex among patients from different global regions (CRACKLE-2): a …

M Wang, M Earley, L Chen, BM Hanson… - The Lancet Infectious …, 2022 - thelancet.com
Summary Background Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a global
threat. We therefore analysed the bacterial characteristics of CRKP infections and the …

Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread

S David, S Reuter, SR Harris, C Glasner, T Feltwell… - Nature …, 2019 - nature.com
Public health interventions to control the current epidemic of carbapenem-resistant
Klebsiella pneumoniae rely on a comprehensive understanding of its emergence and …

[HTML][HTML] Genomic dissection of Klebsiella pneumoniae infections in hospital patients reveals insights into an opportunistic pathogen

CL Gorrie, M Mirčeta, RR Wick, LM Judd… - Nature …, 2022 - nature.com
Klebsiella pneumoniae is a major cause of opportunistic healthcare-associated infections,
which are increasingly complicated by the presence of extended-spectrum beta-lactamases …

Hypervirulent Klebsiella pneumoniae – clinical and molecular perspectives

JE Choby, J Howard‐Anderson… - Journal of internal …, 2020 - Wiley Online Library
Hypervirulent Klebsiella pneumoniae (hvKp) has emerged as a concerning global
pathogen. hvKp is more virulent than classical K. pneumoniae (cKp) and capable of causing …

A fatal outbreak of ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae in a Chinese hospital: a molecular epidemiological study

D Gu, N Dong, Z Zheng, D Lin, M Huang… - The Lancet infectious …, 2018 - thelancet.com
Summary Background Hypervirulent Klebsiella pneumoniae strains often cause life-
threatening community-acquired infections in young and healthy hosts, but are usually …

[HTML][HTML] Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection

AC Dowell, MS Butler, E Jinks, G Tut, T Lancaster… - Nature …, 2022 - nature.com
SARS-CoV-2 infection is generally mild or asymptomatic in children but a biological basis for
this outcome is unclear. Here we compare antibody and cellular immunity in children (aged …

Assembly of bacterial capsular polysaccharides and exopolysaccharides

C Whitfield, SS Wear, C Sande - Annual Review of Microbiology, 2020 - annualreviews.org
Polysaccharides are dominant features of most bacterial surfaces and are displayed in
different formats. Many bacteria produce abundant long-chain capsular polysaccharides …

Adaptive evolution of virulence and persistence in carbapenem-resistant Klebsiella pneumoniae

CM Ernst, JR Braxton, CA Rodriguez-Osorio… - Nature medicine, 2020 - nature.com
Among the most urgent public health threats is the worldwide emergence of carbapenem-
resistant Enterobacteriaceae,,–, which are resistant to the antibiotic class of 'last resort'. In …