Proliferation markers, such as proliferating cell nuclear antigen (PCNA), Ki-67, and
thymidine kinase 1 (TK1), have potential as diagnostic tools and as prognostic factors in …

Gene and antisense/ribozyme therapy possesses tremendous potential for the successful
treatment of genetically based diseases, such as cancer. Several cancer gene therapy …

The therapeutic efficacy of adenovirus-mediated herpes simplex virus thymidine kinase
(HSV-tk) gene transduction of rat C6 glioma cells followed by ganciclovir (GCV) …

Intratumoral implantation of murine cells modified to produce retroviral vectors containing
the herpes simplex virus-thymidine kinase (HSV-TK) gene induces regression of …

Herpes simplex virus type 1 (HSV-1) thymidine kinase is currently used as a suicide agent in
the gene therapy of cancer. This therapy is based on the preferential phosphorylation of …

Antitumor suicide gene therapy is one of the emerging strategies against cancer. It consists
of the introduction into cancer cells of a gene capable of converting a nontoxic prodrug into a …

This review is a survey of various approaches to targeting cytotoxic anticancer drugs to
tumors primarily through biomolecules expressed by cancer cells or associated vasculature …

In situ killing of tumor cells using suicide gene transfer to generate death by a non-apoptotic
pathway was associated with high immunogenicity and induction of heat shock protein (hsp) …

Over the past few years, technological procedures have been developed for utilizing stem
cells in transplantation medicine. Human embryonic stem (ES) cells can produce an …

Cell therapy with polyclonal regulatory T cells (Tregs) has been translated into the clinic and
is currently being tested in transplant recipients and patients suffering from autoimmune …