Several large-scale genomic studies have supported an association between cases of
autism spectrum disorder and mutations in the genes SH3 and multiple ankyrin repeat …

Brain-derived neurotrophic factor (BDNF) is an important regulator of synaptic transmission
and long-term potentiation (LTP) in the hippocampus and in other brain regions, playing a …

Cellular granules lacking boundary membranes harbor RNAs and their associated proteins
and play diverse roles controlling the timing and location of protein synthesis. Formation of …

Autism spectrum disorders (ASD) are pervasive neurodevelopmental disorders that include
a variety of forms and clinical phenotypes. This heterogeneity complicates the clinical and …

In neurons, dendritic protein synthesis is required for many forms of long-term synaptic
plasticity. The population of mRNAs that are localized to dendrites, however, remains …

The elaborate morphology of neurons together with the information processing that occurs in
remote dendritic and axonal compartments makes the use of decentralized cell biological …

Shank family proteins (Shank1, Shank2, and Shank3) are synaptic scaffolding proteins that
organize an extensive protein complex at the postsynaptic density (PSD) of excitatory …

Abstract The 22q13. 3 deletion syndrome, also known as Phelan-McDermid syndrome, is a
contiguous gene disorder resulting from deletion of the distal long arm of chromosome 22. In …

A class of small, non-coding transcripts called microRNAs (miRNAs) that provide a crucial
and pervasive layer of post-transcriptional gene regulation has recently emerged and …

Genetic studies have revealed significant overlaps of risk genes among psychiatric
disorders. However, it is not clear how different mutations of the same gene contribute to …