Mitochondrial DNA (mtDNA) encodes essential components of the cellular energy-
producing apparatus, and lesions in mtDNA and mitochondrial dysfunction contribute to …

The discovery 20 years ago that some RNA molecules, called ribozymes, are able to
catalyze chemical reactions was a breakthrough in biology. Over the last two decades …

Mitochondrial transcription factor A (TFAM), a member of the high mobility group proteins, is
essential for maintenance of mitochondrial DNA (mtDNA). Most TFAM and mtDNA (both of …

Lon is the major protease in the mitochondrial matrix in eukaryotes, and is well conserved
among species. Although a role for Lon in mitochondrial biogenesis has been proposed, the …

Mitochondrial transcription factor A (TFAM), a transcription factor for mitochondrial DNA
(mtDNA) that also possesses the property of nonspecific DNA binding, is essential for …

Oxidative phosphorylation (OXPHOS), the intracellular process that generates the majority of
the ATP of a cell through the electron-transfer chain, is highly dependent on proteins …

During replication, mitochondrial DNA (mtDNA) takes on a triple‐stranded structure called a
D‐loop. Although their physiological roles are not understood, D‐loops are implicated in …

We have previously identified and characterized Drosophila hemolectin (Hml) in the
conditioned medium of a Drosophila cell line. The deduced amino acids sequence contains …

In addition to its central role in cellular stress signaling, the tumor suppressor p53 modulates
mitochondrial respiration through its nuclear transcription factor activity and localizes to …

Mitochondrial quality control and apoptosis have been described as key components in the
pathogenesis of nonalcoholic steatohepatitis (NASH); exercise is recognized as a …