Plaque microvascularization and increased endothelial permeability are key players in the
development of atherosclerosis, from the initial stages of plaque formation to the occurrence …

Background Cancer cells favor the use of less efficient glycolysis rather than mitochondrial
oxidative phosphorylation to metabolize glucose, even in oxygen-rich conditions, a distinct …

Atherosclerosis is a common cardiovascular disease caused by the abnormal expression of
multiple factors and genes influenced by both environmental and genetic factors. The …

Glycolysis emerges as a new therapeutic target for malignancies. The inhibition of glycolytic
activator, PFKFB3, repairs tumor endothelial cell function, and normalizing the tumor …

Vascular biology is an important scientific domain that has gradually penetrated many
medical and scientific fields. Scientists are most often focused on present problems in their …

Vasa vasorum are blood microvessels which penetrate the adventitia and outer layers of the
media of large blood vessels, supplying them with nutrients and oxygen. A growing body of …

Ascorbic acid (vitamin C) elicits pleiotropic effects in the body. Among its functions, it serves
as a potent anti-oxidant, a co-factor in collagen and catecholamine synthesis, and a …

Atherosclerosis is a complex multifactorial disease that affects large and medium-sized
arteries. Rupture of atherosclerotic plaques and subsequent acute cardiovascular …

The term angiogenesis arose in the 18th century. Several studies over the next 100 years
laid the groundwork for initial studies performed by the Folkman laboratory, which were at …

Endothelial cell (EC) senescence is increasingly recognized as a significant contributor to
the development of vascular dysfunction and age-related disorders and diseases, including …