Albuminuria is the hallmark of both primary and secondary proteinuric glomerulopathies,
including focal segmental glomerulosclerosis (FSGS), obesity-related nephropathy, and …

Podocytes maintain the glomerular filtration barrier, and the stability of this barrier depends
on their highly differentiated postmitotic phenotype, which also defines the particular …

Background: Podocyte biology is a developing science that promises to help improve
understanding of the mechanistic nature of multiple diseases associated with proteinuria …

The function of the kidney, filtering blood and concentrating metabolic waste into urine, takes
place in an intricate and functionally elegant structure called the renal glomerulus. Normal …

Podocytes are highly specialized cells of the kidney glomerulus that wrap around capillaries
and that neighbor cells of the Bowman's capsule. When it comes to glomerular filtration …

Diabetic nephropathy is the major cause of end‐stage renal failure throughout the world in
both developed and developing countries. Diabetes affects all cell types of the kidney …

Genetic studies of hereditary forms of nephrotic syndrome have identified several proteins
that are involved in regulating the permselective properties of the glomerular filtration …

Nephrotic syndrome (NS) is divided into steroid-sensitive (SSNS) and-resistant (SRNS)
variants. SRNS causes end-stage kidney disease, which cannot be cured. While the disease …

Steroid-resistant nephrotic syndrome (SRNS) is a frequent cause of progressive renal
function decline and affects millions of people. In a recent study, 30% of SRNS cases …

Podocytes exhibit a unique cytoskeletal architecture that is fundamentally linked to their
function in maintaining the kidney filtration barrier. The cytoskeleton regulates podocyte …